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Dietary genistein disrupts sex steroid and vitellogenic response in female common carp, Cyprinus carpio L.

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Title Dietary genistein disrupts sex steroid and vitellogenic response in female common carp, Cyprinus carpio L.
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Creator Nuzaiba PM, Varghese T, Gupta S*, Sahu NP, Banani M, Srivastava PP, Krishna G.
 
Subject Genistein Vitellogenesis Estrogen receptor Testosterone Ovarian aromatase
 
Description Not Available
A 60-day feeding trial was conducted to evaluate the impact of dietary genistein on steroidogenesis and vi- tellogenesis pattern in female common carp, Cyprinus carpio L. Adult female C. carpio were fed with graded levels of genistein in different groups is 0 (Control), 1 (Gen-1), 3 (Gen-3), 6 (Gen-6) and 9 (Gen-9) mg% of feed. As a result, inclusion of genistein significantly reduced the number and size of vitellogenic oocyte in the ovary of C. carpio. Serum vitellogenin (VTG) concentration as well as the expression of erβ and vtgb2 in liver were sig- nificantly reduced in genistein fed female C. carpio. Serum testosterone and 17β-estradiol (E2) concentration in female C. carpio were increased with increasing dose of genistein, whereas the expression of cyp19a from the
ovary was downregulated in genistein fed C. carpio. The study concludes that structural resemblance of genistein to endogenous estrogen may have led to competing with E2 for binding to estrogen receptors of the liver, which further impaired vitellogenin synthesis and hence created steroid hormonal imbalance. These endocrine dis-
rupting events caused an impairment in ovarian growth of C. carpio.
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Date 2022-06-16T08:11:34Z
2022-06-16T08:11:34Z
2020-02-01
 
Type Research Paper
 
Identifier Not Available
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http://krishi.icar.gov.in/jspui/handle/123456789/72714
 
Language English
 
Relation Not Available;
 
Publisher ELSEVIER