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Multiresidue analysis of captan, captafol, folpet, and iprodione in cereals

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Title Multiresidue analysis of captan, captafol, folpet, and iprodione in cereals
Not Available
 
Creator Shinde R., Shiragave P., Lakade A., Thorat P., Banerjee Kaushik
 
Subject Multi-residue analysis of captan, captafol, folpet, and iprodione in cereals
LC-MS/MS
 
Description Not Available
In this study, we propose an improved analytical method for the multiresidue analysis of captan (plus its metabolite, tetrahydrophthalimide), folpet (plus its metabolite, phthalimide), captafol, and iprodione in cereals using liquid chromatography tandem mass spectrometry (LC-MS/MS). As captan, captafol, and folpet are easily degraded during homogenisation and extraction, samples were comminuted with liquid nitrogen, and both QuEChERS and ethyl acetate-based extraction workflows provided a satisfactory method performance. The optimised LC-MS/MS procedure with electrospray ionisation did not degrade these compounds, and offered sufficient method selectivity by resolving and minimising co-eluting matrix-derived interferences. The method also resolved the problem of non-specific mass spectra that these compounds usually produce on GC-MS analysis involving electron ionisation. The method performance was satisfactory for all 6 compounds at 0.01 mg kg−1 and higher levels of fortification, and validated as per the SANTE/11813/2017 guidelines of analytical quality control in a wide range of cereals including rice, wheat, sorghum, and corn. The method provides special advantage of simultaneous analysis of captan, and folpet along with their metabolites (tetrahydrophthalimide, and phthalimide, respectively) in combination with captafol, and iprodione in a single chromatographic run. Although iprodione is known to degrade to 3,5-dichloroaniline, since this metabolite is not a part of the residue definition, it was not included in the scope of this method. As the method demonstrates satisfactory selectivity, sensitivity, accuracy, precision, and robustness in a wide range of cereal matrices, it is recommended for regulatory testing of these compounds in cereals.
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Date 2020-07-31T06:22:45Z
2020-07-31T06:22:45Z
2019-09-19
 
Type Journal
 
Identifier Shinde R., Shiragave P., Lakade A., Thorat P., Banerjee Kaushik (2019). Multiresidue analysis of captan, captafol, folpet, and iprodione in cereals. Food Additives and Contaminants Part A https://doi.org/10.1080/19440049.2019.1662953
https://doi.org/10.1080/19440049.2019.1662953
http://krishi.icar.gov.in/jspui/handle/123456789/38646
 
Language English
 
Relation Not Available;
 
Publisher Taylor & Francis