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<p>Synthesis and antitumor activity of novel <em>N</em>-(8-(3-ureidophenyl)imidazo [1,2-a]pyridin-6-yl)acetamide derivatives</p>

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Title Statement <p>Synthesis and antitumor activity of novel <em>N</em>-(8-(3-ureidophenyl)imidazo [1,2-a]pyridin-6-yl)acetamide derivatives</p>
 
Added Entry - Uncontrolled Name Chen, Yu-Mei ; School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang 550025, China
Chen, Dong-Mei ; School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang 550025, China
Wu, Qing-Mei ; School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang 550025, China
Ye, Wen-Jun ; School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang 550025, China
Zhao, Chun-Shen ; School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang 550025, China
Zhou, Zhi-Xu ; School of Pharmaceutical Sciences, Guizhou University, Guiyang 550025, China Guizhou Engineering Laboratory for Synthetic Drugs, Guiyang 550025, China Department of Dermatology, Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, China
 
Uncontrolled Index Term Imidazo[1,2-a]pyridine, Urea, Antitumor activity
 
Summary, etc. <p style="text-align: justify;">A series of <em>N</em>-(8-(3-ureidophenyl)imidazo[1,2-a]pyridin-6-yl)acet- amide derivatives have been designed and synthesized and evaluated for antitumor activity against SMMC7721 cells and HCT116 cells <em>in vitro</em> in order to initially screen out their biological properties and to reveal the role of 8-substituted urea phenyl imidazo[1,2-a]pyridine fragment in the ability of compounds to antitumor activity. The antitumor activity test have shown that most compounds exhibit excellent anticancer activity against SMMC7721 cells and HCT116 cells. The experimental results have proved that <em>N</em>-(8-(3-ureidophenyl)imidazo[1,2-a]pyridin-6-yl)acetamide derivatives containing imidazo[1,2-a]pyridine and urea are promising for further in-depth study of antitumor properties.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-12-19 17:29:37
 
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http://op.niscair.res.in/index.php/IJC/article/view/69444
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 12 (2022): Indian Journal of Chemistry-(IJC)
 
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