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<p>Synthesis of 2-[{2-(1-Acyl-3-aryl-4,5-dihydro-1<em>H­-</em>pyrazol-5-yl)phenoxy}methyl]-5-aryl-1,3,4-oxadiazoles and related compounds as potential pesticides</p>

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Title Statement <p>Synthesis of 2-[{2-(1-Acyl-3-aryl-4,5-dihydro-1<em>H­-</em>pyrazol-5-yl)phenoxy}methyl]-5-aryl-1,3,4-oxadiazoles and related compounds as potential pesticides</p>
 
Added Entry - Uncontrolled Name Saini, Chhavi ; Department of Chemistry, CCS Haryana Agricultural University, Hisar 125 004, India
Sangwan, Naresh K; Department of Chemistry, CCS Haryana Agricultural University, Hisar 125 004, India
 
Uncontrolled Index Term Dihydropyrazoles, Oxadiazoles, Pyrazolyloxadiazoles, Antifungal activity, Pesticidal activity
 
Summary, etc. <p style="text-align: justify;">Cyclization of substituted chalkones <strong>3a,b</strong> with hydrazine hydrate followed by acylation of the resulting 3-aryl-4,5-dihydro-5-(2-hydroxyphenyl)-1<em>H</em>-pyrazoles (<strong>4a,b</strong>) with alkanoic acids furnished 1-acyl-3-aryl-4,5-dihydro-5-(2-hydroxyphenyl)-1<em>H</em>-pyrazoles (<strong>5a-d</strong>).  The compounds <strong>5a-d</strong> are also directly prepared by refluxing <strong>3a,b</strong> with hydrazine hydrate in alkanoic acids. Alkylation of <strong>5a-d</strong> with ethyl chloroacetate have been yielded the corresponding aryloxyacetates <strong>6a-d</strong>.  Aminolysis of the ester <strong>6a-d</strong> have resulted in the formation of corresponding substituted aryloxyacetamides <strong>7a-l</strong>.  Hydrazinolysis of esters <strong>6a-d</strong> with hydrazine hydrate followed by cyclization of the resulting aryloxyacetic acid hydrazides <strong>8a-d</strong> with aromatic acids in refluxing POCl<sub>3</sub> have afforded the title compounds <strong>9a-t</strong>. The compounds <strong>3-9</strong> have been evaluated for their <em>in vitro</em> growth-inhibitory activity against four fungal pests, <em>Alternaria helianthus, Colletotrichum falcatum, fusarium oxysporum </em>and<em> Rhizoctonia solani</em>.  Many of the compounds have displayed promising activity at different concentrations ranging from 313 – 100 mg L<sup>-1</sup>.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-12-19 17:29:37
 
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http://op.niscair.res.in/index.php/IJC/article/view/69441
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 12 (2022): Indian Journal of Chemistry-(IJC)
 
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