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Construction, characterization and antibacterial activity of pyrazolone, thiohydantoin and their derivatives

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Title Statement Construction, characterization and antibacterial activity of pyrazolone, thiohydantoin and their derivatives
 
Added Entry - Uncontrolled Name Michael, Osahon ; Department of Chemistry, Mewar University, Chittogarh, Rajasthan 312 901, India
Tailor, Giriraj ; Department of Chemistry, Mewar University, Chittogarh, Rajasthan 312 901, India
Singh, Saurabh ; Department of Chemistry, M.L.V. Govt. College, Bhilwara, Rajasthan 311 001, India,
Sarma, Bhupendra Kr.; Department of Chemistry, Mewar University, Chittogarh, Rajasthan 312 901, India
Teli, Pankaj ; Department of Life Science, Mewar University, Chittogarh, Rajasthan 312901, India
 
Uncontrolled Index Term Antibacterial activity, Hydantoin, Pyrazole, Pyrazolone, Thiohydantoin
 
Summary, etc. Heterocyclic organic compounds play pivotal roles in drug synthesis and continue to remain a fundamental area of research interest. The present study reports the synthesis, characterization and antibacterial activities of synthesized organic compounds containing pyrazolone and thiohydantoin moieties. Pyrazolone and thiohydantoin scaffolds have been constructed using well-defined methods and their derivatives have been synthesized Structural elucidation has been achieved via IR and NMR spectroscopy techniques. The synthesized compounds have been screened for antimicrobial activity at <br /> 50 μg/mL concentration, against three pathogenic micro-organisms, viz: <em>E. coli, K. pneumonia and P. aeruginosa, </em>using the agar diffusion cup plate method. Ciprofloxacin is used as control. Interestingly, all the compounds have exhibited antimicrobial activities. Compound 2b have shown the highest sensitivity against <em>P. aeruginosa</em> with ZOI of 13 mm. Compounds 1a and 2a have shown highest activity against <em>K.pneumonia</em>with ZOI 11 mm each. Compound 2a has shown highest sensitivity against <em>E. coli </em>with ZOI of 8 mm. These findings indicate that the synthesized compounds are pure and possess therapeutic properties.
 
Publication, Distribution, Etc. Indian Journal of Chemistry (IJC)
2022-12-19 17:29:37
 
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http://op.niscair.res.in/index.php/IJC/article/view/69452
 
Data Source Entry Indian Journal of Chemistry (IJC); ##issue.vol## 61, ##issue.no## 12 (2022): Indian Journal of Chemistry-(IJC)
 
Language Note en