miRNALoc: predicting miRNA subcellular localizations based on principal component scores of physico-chemical properties and pseudo compositions of di-nucleotides
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Title |
miRNALoc: predicting miRNA subcellular localizations based on principal component scores of physico-chemical properties and pseudo compositions of di-nucleotides
Not Available |
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Creator |
Prabina Kumar Meher
Subhrajit Satpathy Atmakuri Ramakrishna Rao |
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Subject |
MicroRNAs
homeostasis subcellular nucleotides |
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Description |
Not Available
MicroRNAs (miRNAs) are one kind of non-coding RNA, play vital role in regulating several physiological and developmental processes. Subcellular localization of miRNAs and their abundance in the native cell are central for maintaining physiological homeostasis. Besides, RNA silencing activity of miRNAs is also influenced by their localization and stability. Thus, development of computational method for subcellular localization prediction of miRNAs is desired. In this work, we have proposed a computational method for predicting subcellular localizations of miRNAs based on principal component scores of thermodynamic, structural properties and pseudo compositions of di-nucleotides. Prediction accuracy was analyzed following fivefold cross validation, where ~ 63-71% of AUC-ROC and ~ 69-76% of AUC-PR were observed. While evaluated with independent test set, > 50% localizations were found to be correctly predicted. Besides, the developed computational model achieved higher accuracy than the existing methods. A user-friendly prediction server "miRNALoc" is freely accessible at https://cabgrid.res.in:8080/mirnaloc/ , by which the user can predict localizations of miRNAs. Not Available |
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Date |
2022-08-05T07:39:37Z
2022-08-05T07:39:37Z 2020-09-03 |
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Type |
Research Paper
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Identifier |
Meher, P.K., Satpathy, S. & Rao, A.R. miRNALoc: predicting miRNA subcellular localizations based on principal component scores of physico-chemical properties and pseudo compositions of di-nucleotides. Sci Rep 10, 14557 (2020). https://doi.org/10.1038/s41598-020-71381-4
Not Available http://krishi.icar.gov.in/jspui/handle/123456789/73716 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Not Available
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