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miRNALoc: predicting miRNA subcellular localizations based on principal component scores of physico-chemical properties and pseudo compositions of di-nucleotides

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Title miRNALoc: predicting miRNA subcellular localizations based on principal component scores of physico-chemical properties and pseudo compositions of di-nucleotides
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Creator Prabina Kumar Meher
Subhrajit Satpathy
Atmakuri Ramakrishna Rao
 
Subject MicroRNAs
homeostasis
subcellular
nucleotides
 
Description Not Available
MicroRNAs (miRNAs) are one kind of non-coding RNA, play vital role in regulating several physiological and developmental processes. Subcellular localization of miRNAs and their abundance in the native cell are central for maintaining physiological homeostasis. Besides, RNA silencing activity of miRNAs is also influenced by their localization and stability. Thus, development of computational method for subcellular localization prediction of miRNAs is desired. In this work, we have proposed a computational method for predicting subcellular localizations of miRNAs based on principal component scores of thermodynamic, structural properties and pseudo compositions of di-nucleotides. Prediction accuracy was analyzed following fivefold cross validation, where ~ 63-71% of AUC-ROC and ~ 69-76% of AUC-PR were observed. While evaluated with independent test set, > 50% localizations were found to be correctly predicted. Besides, the developed computational model achieved higher accuracy than the existing methods. A user-friendly prediction server "miRNALoc" is freely accessible at https://cabgrid.res.in:8080/mirnaloc/ , by which the user can predict localizations of miRNAs.
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Date 2022-08-05T07:39:37Z
2022-08-05T07:39:37Z
2020-09-03
 
Type Research Paper
 
Identifier Meher, P.K., Satpathy, S. & Rao, A.R. miRNALoc: predicting miRNA subcellular localizations based on principal component scores of physico-chemical properties and pseudo compositions of di-nucleotides. Sci Rep 10, 14557 (2020). https://doi.org/10.1038/s41598-020-71381-4
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http://krishi.icar.gov.in/jspui/handle/123456789/73716
 
Language English
 
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Publisher Not Available