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High throughput residue analysis of indaziflam and its metabolites in palm oil using liquid chromatography - tandem mass spectrometry

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Title High throughput residue analysis of indaziflam and its metabolites in palm oil using liquid chromatography - tandem mass spectrometry
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Creator Halim N., Kuntom A., Shinde R., Banerjee Kaushik
 
Subject Indaziflam and its metabolites
Palm oil
LC-MS/MS
 
Description Not Available
Background and objective
Indaziflam (IND) is a herbicide, which is used in palm oil plantations for broad spectrum management of weeds. Till date, no validated method is available for residue estimation of this herbicide in palm oil products. In this study, we report a rapid method for the residue analysis of IND and its metabolites, viz., IND-carboxylic acid, diaminotriazine, and triazine indanone in a wide range of palm oil matrices using liquid chromatography tandem mass spectrometry (LC-MS/MS).

Method
The optimised sample preparation workflows included two options: (A) acetonitrile extraction (QuEChERS workflow), followed by freezing at -80 °C and (B) acetonitrile extraction, followed by cleanup through a C18 solid phase extraction (SPE) cartridge. The optimised LC rutime was 7 min. All these analytes were estimated by LC-MS/MS multiple reaction monitoring.

Results
Both sample preparation methods provided a similar method performance and acceptable results. The limit of quantification (LOQ) of IND, IND-carboxylic acid and triazine indanone was 0.001 mg/kg. For diaminotriazine, the LOQ was 0.005 mg/kg. The method accuracy and precision complied with the SANTE/12682/2019 guidelines of analytical quality control.

Conclusion
The potentiality of the method lies in a high throughput analysis of IND and its metabolites in a single chromatographic run with high selectivity and sensitivity. Considering its fit-for-purpose performance, the method can be implemented in regulatory testing of IND residues in a wide range of palm oil matrices that are consumed and traded worldwide.
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Date 2020-08-01T15:45:10Z
2020-08-01T15:45:10Z
2020-03-20
 
Type Journal
 
Identifier Halim N., Kuntom A., Shinde R., Banerjee Kaushik (2020). High throughput residue analysis of indaziflam and its metabolites in palm oil using liquid chromatography - tandem mass spectrometry. Journal of AOAC International https://doi.org/10.1093/jaoacint/qsaa041
https://academic.oup.com/jaoac/article-abstract/doi/10.1093/jaoacint/qsaa041/5810488?redirectedFrom=fulltext
http://krishi.icar.gov.in/jspui/handle/123456789/38867
 
Language English
 
Relation Not Available;
 
Publisher Oxford University Press