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Precise plant genome editing using base editors and prime editors

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Title Precise plant genome editing using base editors and prime editors
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Creator Kutubuddin A Molla, Simon Sretenovic, Kailash C Bansal, Yiping Qi
 
Subject CRISPR–Cas, genome editing, Prime editing, Plants, Precision editing
 
Description Not Available
The development of CRISPR–Cas systems has sparked a genome editing revolution in plant genetics and breeding. These sequence-specific RNA-guided nucleases can induce DNA double-stranded breaks, resulting in mutations by imprecise non-homologous end joining (NHEJ) repair or precise DNA sequence replacement by homology-directed repair (HDR). However, HDR is highly inefficient in many plant species, which has greatly limited precise genome editing in plants. To fill the vital gap in precision editing, base editing and prime editing technologies have recently been developed and demonstrated in numerous plant species. These technologies, which are mainly based on Cas9 nickases, can introduce precise changes into the target genome at a single-base resolution. This Review provides a timely overview of the current status of base editors and prime editors in plants, covering both technological developments and biological applications.
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Date 2022-03-25T10:04:27Z
2022-03-25T10:04:27Z
2021-09-13
 
Type Review Paper
 
Identifier Molla, K.A., Sretenovic, S., Bansal, K.C. et al. Precise plant genome editing using base editors and prime editors. Nat. Plants 7, 1166–1187 (2021). https://doi.org/10.1038/s41477-021-00991-1
https://www.nature.com/articles/s41477-021-00991-1
http://krishi.icar.gov.in/jspui/handle/123456789/70593
 
Language English
 
Relation Not Available;
 
Publisher Springer