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Antioxidant drimane‐type sesquiterpenoid from muricid gastropod Chicoreus ramosus attenuates pro‐inflammatory 5‐lipoxygenase and carbolytic enzymes

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Title Antioxidant drimane‐type sesquiterpenoid from muricid
gastropod Chicoreus ramosus attenuates pro‐inflammatory
5‐lipoxygenase and carbolytic enzymes
Not Available
 
Creator Chakraborty,Kajal
Salas,Soumya
 
Subject antioxidant, carbolytic enzymes, Chicoreus ramosus, drimane‐type sesquiterpenoid, gastropod
mollusk, health food, Muricidae, pro‐inflammatory 5‐lipoxygenase, Ramosane
 
Description Not Available
The muricid gastropod, Chicoreus ramosus, is a nutrient‐enriched food source available
along the coastal peninsular of the Indian subcontinent. This study was aimed at
bioactivity‐directed chromatographic fractionation of the organic extract of C. ramosus
to isolate an unprecedented drimane‐type sesquiterpenoid Ramosane, characterized
as 3‐hydroxy‐7,9b‐dimethyl‐5‐methylene‐8‐pentyl‐octahydro‐1H‐cyclopenta[a]
naphthalen‐9(2H)‐one. The compound possessed potential antioxidant activities [2,
2′‐diphenyl‐1‐picryl hydrazyl (DPPH) and 2,2′‐azino‐bis 3‐ethylbenzothiazoline‐6‐
sulfonic acid (ABTS) radical scavenging activities of IC50 1.42 mM and 1.72 mM, respectively]
and was proportionate with those (IC50 1.39 and 1.69 mM, respectively)
exhibited by α‐tocopherol. The studied sesquiterpenoid exhibited potential attenuation
property countering the pro‐inflammatory 5‐lipoxygenase (IC50 ~ 4 mM), and its
activity was analogous with that exhibited by the anti‐inflammatory ibuprofen (IC50
4.36 mM), whereas its carbolytic α ‐ amylase activity (IC50 0.96 mM) was commensurate
with that displayed by acarbose (IC50 0.43 mM). The isolated metabolite might
anticipate as potential naturally derived bioactive constituent in functional food and
pharmaceutical applications.
Not Available
 
Date 2021-09-18T03:59:34Z
2021-09-18T03:59:34Z
2019
 
Type Article
 
Identifier Not Available
1745–4514
http://krishi.icar.gov.in/jspui/handle/123456789/64151
 
Language English
 
Relation Not Available
 
Publisher Not Available