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Cardioprotective Effect of Squalene on Lipid Profile in Isoprenaline-Induced Myocardial Infarction in Rats

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Title Cardioprotective Effect of Squalene on Lipid Profile in Isoprenaline-Induced Myocardial Infarction in Rats
Not Available
 
Creator Sabeena Farvin, K. H.
Anandan, R.
Hari Senthil Kumar, S.
Shiny, K. S.
Suseela Mathew
Sankar, T. V.
Viswanathan Nair, P. G.
 
Subject isoprenaline
lipid peroxidation
lipids
myocardial infarction
squalene
 
Description Not Available
We studied the cardioprotective effect of squalene on isoprenaline-induced myocardial infarction in male albino rats with respect to changes in the levels of lipid components in plasma and heart tissue. Prior administration of 2% squalene in feed for 45 days significantly reduced the isoprenaline-induced elevation in the levels of cholesterol, triglycerides, and free fatty acids in plasma and heart tissue of rats following myocardial infarction. It exerted an antilipidemic effect by reducing the level of low-density lipoprotein cholesterol with a parallel rise in the level of high-density lipoprotein cholesterol in plasma of experimental rats. A tendency to prevent the isoprenaline-induced depletion of phospholipids in the myocardium of experimental rats was also observed. In the present study, the pretreatment with squalene significantly counteracted the isoprenaline-induced lipid peroxidation and maintained the rats at near normal status. The results of the present study indicate that the overall cardioprotective effect of squalene is probably related to an inhibition of lipid accumulation by its hypolipidemic properties and/or its antioxidant properties.
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Date 2021-11-09T09:09:44Z
2021-11-09T09:09:44Z
2006-01-04
 
Type Research Paper
 
Identifier Sabeena Farvin, K. H., Anandan, R., Hari Senthil Kumar, S., Shiny, K. S., Suseela Mathew, Sankar, T. V. and Viswanathan Nair, P. G. (2006) Cardioprotective Effect of Squalene on Lipid Profile in Isoprenaline-Induced Myocardial Infarction in Rats. Journal of Medicinal Food. 9(4): 531-536.
1096-620X
http://krishi.icar.gov.in/jspui/handle/123456789/67187
 
Language English
 
Relation Not Available;
 
Publisher Mary Ann Liebert,Inc