Record Details

Two rare antioxidative prenylated terpenoids from loop-root Asiatic mangrove Rhizophora mucronata (Family Rhizophoraceae) and their activity against pro-inflammatory cyclooxygenases and lipoxidase

KRISHI: Publication and Data Inventory Repository

View Archive Info
 
 
Field Value
 
Title Two rare antioxidative prenylated terpenoids from
loop-root Asiatic mangrove Rhizophora mucronata (Family
Rhizophoraceae) and their activity against pro-inflammatory
cyclooxygenases and lipoxidase
Not Available
 
Creator Chakraborty,Kajal
Raola,Vamshi Krishna
 
Subject Rhizophora mucronata
prenylated terpenoids
antiinflammatory
antioxidant
structure–activity relationship
 
Description Not Available
Two new biogenic prenylated terpenoids were isolated from the methanol
extract of Rhizophora mucronata. The extended C20 sesquiterpenoid
with prenylated guaiane framework was characterised as (4E, 8Z)-3,
3a, 6, 7-tetrahydro-3, 9-dimethyl-5-(6-methylheptan-2-yl) cycloocta[b]
furan-2-(9aH)-one (1). (35E)-1,2,3,5,6,6-icosahydro-4,4,8b,10,14,17,20,20-
octamethylpicen-3-yl-34,35-dimethyloct-31-enoate (2) represents
the first example of naturally occurring C40 prenylated oleanane-type
triterpenoid, whereas one 4,5-dimethyloct-5-enoate side chain remains
attached at C-3 position of the oleanane framework formed by the E-ring
closure of C30 saccharide moiety. The structures of the compounds were
elucidated using NMR and mass spectrometric analysis. Compound 1 was
found to have significantly greater antioxidant activities (IC50 ~ 0.75 mg/
mL) compared to 2 (IC50 > 0.80 mg/mL). No significant differences in
anti-cyclooxygenase-2 of these compounds were discernable (IC50
0.8 – 0.9 mg/mL), whilst compound 1 showed greater anti-5-lipoxidase
activities (IC50 ~ 0.8 mg/mL) those that of 2 (IC50 0.96 mg/mL). Bioactivities
of the prenylated terpenoids were inversely proportional to lipophilic
and bulk descriptors.
Not Available
 
Date 2021-09-17T07:57:02Z
2021-09-17T07:57:02Z
2016
 
Type Article
 
Identifier Not Available
1478-6427 (Online)
http://krishi.icar.gov.in/jspui/handle/123456789/63760
 
Language English
 
Relation Not Available
 
Publisher Taylor and Francis