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New sterols with anti-inflammatory potentials against cyclooxygenase-2 and 5-lipoxygenase from Paphia malabarica

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Title New sterols with anti-inflammatory potentials
against cyclooxygenase-2 and 5-lipoxygenase from
Paphia malabarica
Not Available
 
Creator Raola,Vamshi Krishna
Chakraborty,Kajal
Joy,Minju
 
Subject (22E)-241,242-methyldihomocholest-5,22-dien-3β-ol
23-gem-dimethylcholesta-5-en-3β-ol
Bivalve clam
Paphia malabarica
anti-inflammatory activity
 
Description Not Available
Marine bivalves occupy a leading share in the total edible molluscs
at the coastline regions of south-eastern Asia, and are found to
possess significant nutritional and biological potential. Various
in vitro evaluation (antioxidant and anti-inflammatory) guided
purification of ethyl acetate–methanol (EtOAc–MeOH) extract
of bivalve clam, Paphia malabarica characterised two new sterol
derivatives as 23-gem-dimethylcholesta-5-en-3β-ol (1) and (22E)-
241,242-methyldihomocholest-5,22-dien-3β-ol (2) collected from the
south-west coast of Arabian Sea. Their structures were unambiguously
assigned on the basis of 1D, 2D NMR spectroscopy and mass
spectrometry. The antioxidant and anti-inflammatory activities
of 2 as determined by DPPH/ABTS+ radical scavenging and anticyclooxygenase-
2/5-lipoxygenase assays were significantly greater
(IC50 < 1 mg/mL) than 1 (IC50 > 1 mg/mL). Structure–activity relationship
analysis revealed that the bioactivities of these compounds were
directly proportional to the electronic and lipophilic parameters. This
is the first report of the occurrence and characterisation of 23-gemdimethyl-
3β-hydroxy-Δ5-cholestane nucleus and C-30 dihomosterol
from marine organisms.
Not Available
 
Date 2021-09-17T08:59:19Z
2021-09-17T08:59:19Z
2017
 
Type Article
 
Identifier Not Available
1478-6427 (Online)
http://krishi.icar.gov.in/jspui/handle/123456789/63931
 
Language English
 
Relation Not Available
 
Publisher Taylor and Francis