New sterols with anti-inflammatory potentials against cyclooxygenase-2 and 5-lipoxygenase from Paphia malabarica
KRISHI: Publication and Data Inventory Repository
View Archive InfoField | Value | |
Title |
New sterols with anti-inflammatory potentials against cyclooxygenase-2 and 5-lipoxygenase from Paphia malabarica Not Available |
|
Creator |
Raola,Vamshi Krishna
Chakraborty,Kajal Joy,Minju |
|
Subject |
(22E)-241,242-methyldihomocholest-5,22-dien-3β-ol
23-gem-dimethylcholesta-5-en-3β-ol Bivalve clam Paphia malabarica anti-inflammatory activity |
|
Description |
Not Available
Marine bivalves occupy a leading share in the total edible molluscs at the coastline regions of south-eastern Asia, and are found to possess significant nutritional and biological potential. Various in vitro evaluation (antioxidant and anti-inflammatory) guided purification of ethyl acetate–methanol (EtOAc–MeOH) extract of bivalve clam, Paphia malabarica characterised two new sterol derivatives as 23-gem-dimethylcholesta-5-en-3β-ol (1) and (22E)- 241,242-methyldihomocholest-5,22-dien-3β-ol (2) collected from the south-west coast of Arabian Sea. Their structures were unambiguously assigned on the basis of 1D, 2D NMR spectroscopy and mass spectrometry. The antioxidant and anti-inflammatory activities of 2 as determined by DPPH/ABTS+ radical scavenging and anticyclooxygenase- 2/5-lipoxygenase assays were significantly greater (IC50 < 1 mg/mL) than 1 (IC50 > 1 mg/mL). Structure–activity relationship analysis revealed that the bioactivities of these compounds were directly proportional to the electronic and lipophilic parameters. This is the first report of the occurrence and characterisation of 23-gemdimethyl- 3β-hydroxy-Δ5-cholestane nucleus and C-30 dihomosterol from marine organisms. Not Available |
|
Date |
2021-09-17T08:59:19Z
2021-09-17T08:59:19Z 2017 |
|
Type |
Article
|
|
Identifier |
Not Available
1478-6427 (Online) http://krishi.icar.gov.in/jspui/handle/123456789/63931 |
|
Language |
English
|
|
Relation |
Not Available
|
|
Publisher |
Taylor and Francis
|
|