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Sulphated galactopyran derived from Gracilaria opuntia, a marine macroalgae restores the antioxidant metabolic enzymes during STZ induced diabetic rats

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Title Sulphated galactopyran derived from Gracilaria opuntia, a marine macroalgae restores the antioxidant
metabolic enzymes during STZ induced diabetic rats
Not Available
 
Creator Makkar,Fasina
Anusree,M
Chakraborty,Kajal
Valluru,Lokanatha
Lavanya,R
 
Subject Marine macroalgae
Oxidative stress
Antioxidants
Streptozotocin
Diabetes
 
Description Not Available
In vitro antioxidant assays of FM4 were estimated by DPPH, ABTS, hydroxyl free
radical and Nitric oxide free radical activities. FM4 was purified and characterized by 1H-NMR
spectra and FTIR as sulphated galactopyran. Diabetes was induced intraperitonially by single
dose of STZ (55 mg/kg body weight). FM4 was administrated orally (80, 100, 125 mg/kg BW)
to diabetic rats for 60 days. The enzymatic and non-enzymatic antioxidants such as superoxide
dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione-S-transferase (GST),
lipid peroxidase (LPx), glutathione reduced (GSH), vitamin-C (VIT-C) and vitamin-E (VIT-E)
levels were estimated. Glibenclamide was used as standard drug.
Not Available
 
Date 2021-09-17T09:00:24Z
2021-09-17T09:00:24Z
2017
 
Type Article
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/63979
 
Language English
 
Relation Not Available
 
Publisher Not Available