Two rare antioxidant and anti-inflammatory oleanenes from loop root Asiatic mangrove Rhizophora mucronata
KRISHI: Publication and Data Inventory Repository
View Archive InfoField | Value | |
Title |
Two rare antioxidant and anti-inflammatory oleanenes from loop root Asiatic mangrove Rhizophora mucronata Not Available |
|
Creator |
Raola,Vamshi Krishna
Chakraborty,Kajal |
|
Subject |
Rhizophora mucronata Lam.
Rhizophoraceae Olean-18(19)-en-3β-yl (3, 6-dimethyl-3, 6-dienoate) (13α) 27-Frido-olean-14(15)-en-(17α)-furanyl-3β-ol Antioxidative Cyclooxygenase-2 5-Lipoxygenase Structure activity relationship analysis |
|
Description |
Not Available
Two oleanenes, olean-18(19)-en-3b-yl-(3,6-dimethyl-3E,6Z-dienoate) and (13a)-27-frido-olean-14(15)- en-(17a)-furanyl-3b-ol representing a class of rare natural pentacyclic triterpenoids were isolated from the chloroform extract of Asiatic mangrove, Rhizophora mucronata Lam. (Family: Rhizophoraceae). The furanyl oleanene exhibited significantly greater antioxidative activities (IC50 0.73e0.76 mg/mL), than prenylated oleanene (IC50 0.84e0.96 mg/mL) (P < 0.05). No significant differences in anti-5-lipoxygenase activities of these compounds with the synthetic drug ibuprofen was discernable (IC50 0.8e0.9 mg/mL), whilst furanyl oleanene demonstrated significantly greater anti-cyclooxygenase-2 (IC50 0.84 mg/mL) and anti-5-lipoxygenase activities (IC50 0.78 mg/mL) over prenylated oleanene (IC50 > 0.90 mg/mL). These compounds exhibited lesser activity against cyclooxygenase-1 than cyclooxygenase-2 isoform, and therefore, their selectivity indices remained significantly greater (anti-cyclooxygenase-1IC50/anti-cyclooxygenase- 2IC50 > 1) than the aspirin (0.02) and ibuprofen (0.44). The lipophilic and steric molecular descriptors were found to occupy a prominent role in determining the bioactivities of the compounds. These previously undescribed oleanenes might serve as potential antioxidative and anti-inflammatory lead molecules in medicinal formulations and food industries. Not Available |
|
Date |
2021-09-17T09:00:26Z
2021-09-17T09:00:26Z 2017 |
|
Type |
Article
|
|
Identifier |
Not Available
Not Available http://krishi.icar.gov.in/jspui/handle/123456789/63990 |
|
Language |
English
|
|
Relation |
Not Available
|
|
Publisher |
Not Available
|
|