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Two rare antioxidant and anti-inflammatory oleanenes from loop root Asiatic mangrove Rhizophora mucronata

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Title Two rare antioxidant and anti-inflammatory oleanenes from loop root
Asiatic mangrove Rhizophora mucronata
Not Available
 
Creator Raola,Vamshi Krishna
Chakraborty,Kajal
 
Subject Rhizophora mucronata Lam.
Rhizophoraceae
Olean-18(19)-en-3β-yl (3, 6-dimethyl-3, 6-dienoate)
(13α) 27-Frido-olean-14(15)-en-(17α)-furanyl-3β-ol
Antioxidative
Cyclooxygenase-2
5-Lipoxygenase
Structure activity relationship analysis
 
Description Not Available
Two oleanenes, olean-18(19)-en-3b-yl-(3,6-dimethyl-3E,6Z-dienoate) and (13a)-27-frido-olean-14(15)-
en-(17a)-furanyl-3b-ol representing a class of rare natural pentacyclic triterpenoids were isolated from
the chloroform extract of Asiatic mangrove, Rhizophora mucronata Lam. (Family: Rhizophoraceae). The
furanyl oleanene exhibited significantly greater antioxidative activities (IC50 0.73e0.76 mg/mL), than
prenylated oleanene (IC50 0.84e0.96 mg/mL) (P < 0.05). No significant differences in anti-5-lipoxygenase
activities of these compounds with the synthetic drug ibuprofen was discernable (IC50 0.8e0.9 mg/mL),
whilst furanyl oleanene demonstrated significantly greater anti-cyclooxygenase-2 (IC50 0.84 mg/mL) and
anti-5-lipoxygenase activities (IC50 0.78 mg/mL) over prenylated oleanene (IC50 > 0.90 mg/mL). These
compounds exhibited lesser activity against cyclooxygenase-1 than cyclooxygenase-2 isoform, and
therefore, their selectivity indices remained significantly greater (anti-cyclooxygenase-1IC50/anti-cyclooxygenase-
2IC50 > 1) than the aspirin (0.02) and ibuprofen (0.44). The lipophilic and steric molecular
descriptors were found to occupy a prominent role in determining the bioactivities of the compounds.
These previously undescribed oleanenes might serve as potential antioxidative and anti-inflammatory
lead molecules in medicinal formulations and food industries.
Not Available
 
Date 2021-09-17T09:00:26Z
2021-09-17T09:00:26Z
2017
 
Type Article
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/63990
 
Language English
 
Relation Not Available
 
Publisher Not Available