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Antioxidant and anti-inflammatory oxygenated meroterpenoids from the thalli of red seaweed Kappaphycus alvarezii

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Title Antioxidant and anti-inflammatory oxygenated meroterpenoids
from the thalli of red seaweed Kappaphycus alvarezii
Not Available
 
Creator Chakraborty,Kajal
Makkar,Fasina
 
Subject Kappaphycus alvarezii, Solieriaceae, Oxygenated C29 meroterpenoid, Antioxidant, Anti-inflammatory activity,
Inducible inflammatory mediators
 
Description Not Available
Three antioxidant and anti-inflammatory oxygenated meroterpenoids, 1-(3-methoxypropyl)-2-propylcyclohexane (C13) (1),
3-(methoxymethyl)heptyl 3-(cyclohex-3-enyl) propanoate (C18) (2), and 2-ethyl-6-(4-methoxy-2-((2-oxotetrahydro-2Hpyran-
4-yl)methyl)butoxy)-6-oxohexyl 5-ethyloct-4-enoate (C29) (3) were purified from the methanol:ethyl acetate fraction
of red seaweed Kappaphycus alvarezii (family Solieriaceae) collected from the Gulf-of-Mannar on the southeast coast of
peninsular India. The highly oxygenated C29 meroterpenoid 3 displayed potential antioxidative activities (IC50 < 0.35 mg/
mL) as evaluated by 2, 2’-azino-bis (3-ethylbenzothiazoline)-6-sulphonic acid and 1, 1-diphenyl-2-picryl-hydrazil free
radical scavenging assays. The compound 3 displayed potential in vitro inhibitory activities towards pro-inflammatory 5-
lipoxidase (IC50 1.04 mg/mL), which indicated its potential anti-inflammatory properties against inducible inflammatory
mediators causing an inflammatory response. Structure-activity relationship analyses displayed the functional roles of
lipophilic-hydrophobic characteristics and electronic parameter to determine its potential anti-inflammatory activity in terms
of inhibiting inducible inflammatory cyclooxygenase and lipoxidase.
Not Available
 
Date 2021-09-17T09:00:28Z
2021-09-17T09:00:28Z
2018
 
Type Article
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/64006
 
Language English
 
Relation Not Available
 
Publisher Not Available