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Antioxidative sulphated polygalactans from marine macroalgae as angiotensin-I converting enzyme inhibitors

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Title Antioxidative sulphated polygalactans from marine
macroalgae as angiotensin-I converting enzyme inhibitors
Not Available
 
Creator Chakraborty,Kajal
Makkar,Fasina
 
Subject Sulphated polygalactan
antioxidant activity
angiotensin-I-converting
enzyme
marine macroalgae
 
Description Not Available
Antioxidant and antihypertensive potential of the sulphated
polygalactans isolated from the marine macroalgae Kappaphycus alvarezii
and Gracilaria opuntia were assessed by utilising different in vitro systems.
The galactans isolated from K. alvarezii possessed significantly greater
antioxidative properties as determined by 2,2 - diphenyl - 1 - picrylhydrazyl
(DPPH IC90 0.97 mg / mL) and 2,2′ - azino – bis 3 - ethylbenzothiazoline - 6 -
sulphonic acid (ABTS.+ IC90 0.72 mg / mL) scavenging activities than those
isolated from G. opuntia (DPPH IC90 1.2 mg / mL and ABTS 0.86 mg / mL).
The sulphated polygalactan →4 - 4 - O - sulphonato - (2 - O - methyl) - β - Dgalactopyranosyl - (
1→4) - 3,6 - anhydro - (2 - O - methyl) - α - D - galactopyranan
from K. alvarezii showed greater angiotensin - I - converting enzyme (ACE)
inhibitory activity (IC50 0.02 μg / mL) than →3 - 4 - O - sulphonato - (6 - Oacetyl) -
β - D - galactopyranosyl - (1→4) - 3,6 - anhydro - (2 - O - sulphonato) - α -
D - galactopyranosyl - (1→3) - 4 - O - sulphonato - (6 - O - acetyl) - β - D - xylosyl -
(1→3) - 4 - O - sulphonato - (6 - O - acetyl) - β - D - galactopyranosyl - (1→4) - 3,6 -
anhydro - (2 - O - sulphonato) - α - D - galactopyranan motif extracted from G.
opuntia (IC50 0.70 μg / mL). Structure activity correlation studies displayed
that the ACE inhibitory properties of titled polygalactans were directly
proportional to their electronic properties and inversely with the steric
and hydrophobic characteristics. Putative ACE inhibitory mechanism of
action of sulphated galactans from marine macroalgae corroborated
the structure bioactivity correlation analysis.
Not Available
 
Date 2021-09-17T09:00:29Z
2021-09-17T09:00:29Z
2018
 
Type Article
 
Identifier Not Available
1478-6427 (Online)
http://krishi.icar.gov.in/jspui/handle/123456789/64008
 
Language English
 
Relation Not Available
 
Publisher Taylor and Francis