Antioxidative sulphated polygalactans from marine macroalgae as angiotensin-I converting enzyme inhibitors
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Title |
Antioxidative sulphated polygalactans from marine macroalgae as angiotensin-I converting enzyme inhibitors Not Available |
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Creator |
Chakraborty,Kajal
Makkar,Fasina |
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Subject |
Sulphated polygalactan
antioxidant activity angiotensin-I-converting enzyme marine macroalgae |
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Description |
Not Available
Antioxidant and antihypertensive potential of the sulphated polygalactans isolated from the marine macroalgae Kappaphycus alvarezii and Gracilaria opuntia were assessed by utilising different in vitro systems. The galactans isolated from K. alvarezii possessed significantly greater antioxidative properties as determined by 2,2 - diphenyl - 1 - picrylhydrazyl (DPPH IC90 0.97 mg / mL) and 2,2′ - azino – bis 3 - ethylbenzothiazoline - 6 - sulphonic acid (ABTS.+ IC90 0.72 mg / mL) scavenging activities than those isolated from G. opuntia (DPPH IC90 1.2 mg / mL and ABTS 0.86 mg / mL). The sulphated polygalactan →4 - 4 - O - sulphonato - (2 - O - methyl) - β - Dgalactopyranosyl - ( 1→4) - 3,6 - anhydro - (2 - O - methyl) - α - D - galactopyranan from K. alvarezii showed greater angiotensin - I - converting enzyme (ACE) inhibitory activity (IC50 0.02 μg / mL) than →3 - 4 - O - sulphonato - (6 - Oacetyl) - β - D - galactopyranosyl - (1→4) - 3,6 - anhydro - (2 - O - sulphonato) - α - D - galactopyranosyl - (1→3) - 4 - O - sulphonato - (6 - O - acetyl) - β - D - xylosyl - (1→3) - 4 - O - sulphonato - (6 - O - acetyl) - β - D - galactopyranosyl - (1→4) - 3,6 - anhydro - (2 - O - sulphonato) - α - D - galactopyranan motif extracted from G. opuntia (IC50 0.70 μg / mL). Structure activity correlation studies displayed that the ACE inhibitory properties of titled polygalactans were directly proportional to their electronic properties and inversely with the steric and hydrophobic characteristics. Putative ACE inhibitory mechanism of action of sulphated galactans from marine macroalgae corroborated the structure bioactivity correlation analysis. Not Available |
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Date |
2021-09-17T09:00:29Z
2021-09-17T09:00:29Z 2018 |
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Type |
Article
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Identifier |
Not Available
1478-6427 (Online) http://krishi.icar.gov.in/jspui/handle/123456789/64008 |
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Language |
English
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Relation |
Not Available
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Publisher |
Taylor and Francis
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