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Pharmacological activities of brown seaweed Sargassum wightii (Family Sargassaceae) using different in vitro models

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Title Pharmacological activities of brown seaweed Sargassum wightii
(Family Sargassaceae) using different in vitro models
Not Available
 
Creator Anusree,M
Chakraborty,Kajal
Makkar,Fasina
 
Subject Sargassum wightii, Antioxidant, Anti-inflammatory, Cyclooxygenase, Anti-diabetic, Dipeptidyl peptidase, Antihypertensive, Angiotensin-converting enzyme
 
Description Not Available
Recently a great deal of interest has been developed towards natural
bioactive components from seaweeds as functional food ingredients.
Antioxidant, anti-inflammatory, antidiabetic, and antihypertensive activities
of ethyl acetate:methanol and chloroform solvent fractions of the
brown seaweed Sargassum wightii were evaluated using different in vitro
systems. The ethyl acetate:methanol fraction registered greater Fe2+ ion
chelating ability (IC50 0.52 mg/ml), and were effective in stabilizing the
2,2-azino-bis-3-ethylbenzothiozoline-6-sulfonic acid (IC50 0.82 mg/mL),
and 1,1-diphenyl-2-picryl hydrazil radicals (IC50 0.32 mg/mL) than those
derived from chloroform solvent fractions. The chloroform solvent fraction
showed greater angiotensin converting enzyme-I inhibitory activity
(IC50 0.084 mg/mL), while the ethyl acetate:methanol fraction exhibited
greater anti-COX-1, 2, and 5-LOX (IC50 0.03-0.05 mg/mL) and DPP-4
inhibitory (IC50 ~ 0.013 mg/mL) properties. A significant co-linearity
was recorded between target bioactive properties and the electronegative
groups appeared in the downfield space of the nuclear magnetic
resonance spectra of the ethyl acetate:methanol and chloroform solvent
fractions from S. wightii.
Not Available
 
Date 2021-09-17T09:02:39Z
2021-09-17T09:02:39Z
2017
 
Type Article
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/64037
 
Language English
 
Relation Not Available
 
Publisher Taylor and Francis Online