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Antioxidant and antiinflammatory secondary metabolites from the Asian green mussel Perna viridis

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Title Antioxidant and antiinflammatory secondary metabolites from the Asian green mussel Perna viridis
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Creator Joy,Minju
Chakkalakal,Selsa Jose
Chakraborty,Kajal
 
Subject antioxidant, Asian green mussel, health food, Perna viridis, pro‐inflammatory 5‐lipoxygenase
 
Description Not Available
The Asian green mussel, Perna viridis is a nutritious health food in the estuarine and coastal sea beds of the Arabian Sea along the west coast of India. In the present study, bioactivity‐guided purification of the chloroform fraction of the methanolic extract of P. viridis was carried out. The isolated secondary metabolites were characterized by spectroscopic experiments, and their antioxidative/antiinflammatory properties were evaluated. The titled compounds were characterized as 3‐hydroxy‐13‐vinyl‐dodecahydro‐11‐phenanthrenone (1), 4,4,9‐trimethyl‐13‐vinyl‐dodecahydro‐2‐phenanthrenone (2), 11,20‐dihydroxy‐6,6‐dimethyl‐decahydro‐5H‐benzo[h]naphtho[1,2‐c]chromene‐16‐carbaldehyde (3), 16‐acetyl‐20‐hydroxy‐6,6‐dimethyl‐dodecahydro‐5H‐benzo[h]naphtho[1,2‐c]chromen‐12‐one (4), cholest‐5‐en‐3β‐3‐yl‐(30‐hydroxy‐3‐methyl‐36‐methyleneundeca‐30E,34E‐dienoate) (5), and cholest‐5‐en‐3β‐3‐yl‐((E)‐33‐oxooct‐31‐enoate) (6). No significant differences in the antioxidant activities of the compounds with chromene‐16‐carbaldehyde (3) and chromen‐12‐one (4) functionalities (IC50 0.52–0.68 mg/ml) vis‐à‐vis the positive control, α‐tocopherol (IC50 0.65–0.76 mg/ml) were registered. The studied compounds, 1–4, displayed potential antiinflammatory activities against pro‐inflammatory 5‐lipoxygenase (5‐LOX) (IC50 < 1 mg/ml). The balanced hydrophilic–lipophilic properties and lower steric values of the studied compounds, 1–4, were correlated with their bioactive potentials.
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Date 2021-09-18T03:59:34Z
2021-09-18T03:59:34Z
2019
 
Type Article
 
Identifier Not Available
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http://krishi.icar.gov.in/jspui/handle/123456789/64150
 
Language English
 
Relation Not Available
 
Publisher Not Available