Record Details

Xenicanes attenuate pro-inflammatory 5-lipoxygenase: Prospective natural anti-inflammatory leads from intertidal brown seaweed Padina tetrastromatica

KRISHI: Publication and Data Inventory Repository

View Archive Info
 
 
Field Value
 
Title Xenicanes attenuate pro-inflammatory 5-lipoxygenase: Prospective natural anti-inflammatory leads from intertidal brown seaweed Padina tetrastromatica
Not Available
 
Creator Antony,Tima
Chakraborty,Kajal
 
Subject Padina tetrastromatica
Xenicane-type diterpenoids
Xenicins
Xeniolides
Anti-inflammatory
5-Lipoxygenase enzyme inhibitory
 
Description Not Available
Two previously unreported xenicane class of novaxenicin-type xenicin diterpenoids (1–2) bearing cyclonona[d]furo [2,3-b]pyrandiol and three xeniolide-type diterpenoids with unprecedented octahydrocyclonona[c]pyran-3(1H)-one backbones (3–5) were separated from the organic extract of the intertidal seaweed Padina tetrastomatica (family Dictyotaceae), collected from southern India. The compounds were deduced to bear a xenicane moiety with a 2-oxabicyclo[7.4.0]tridecane cyclic system. The structures of these specialized metabolites were attributed based on the extensive nuclear magnetic resonance spectral analyses, and comparison of related compounds. Xeniolide-type diterpenes (3–5) registered significantly greater attenuation potential against pro-inflammatory 5-lipoxygenase (IC50 ~ 2.04 mM) than that exhibited by non-steroidal anti-inflammatory drug ibuprofen (IC50 4.50 mM, P
Not Available
 
Date 2021-09-18T04:35:49Z
2021-09-18T04:35:49Z
2019
 
Type Article
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/64351
 
Language English
 
Relation Not Available
 
Publisher Not Available