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Sustained delivery of exogenous melatonin influences biomarkers of oxidative stress and total antioxidant capacity in summer stressed anoestrous water buffalo (Bubalus bubalis)

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Title Sustained delivery of exogenous melatonin influences biomarkers of oxidative stress and total antioxidant capacity in summer stressed anoestrous water buffalo (Bubalus bubalis)
Not Available
 
Creator Kumar A
Mehrotra S
Singh G
Narayanan K
Das GK
Soni YK
MAHAK SINGH
Mahla AS
Srivastava N
 
Subject Malondialdehyde
Nitric oxide
Oxidative stress
Free radical
Reactive oxygen species
 
Description Not Available
High ambient temperature during summer in tropical and subtropical countries predisposes
water buffaloes (Bubalus bubalis) to develop oxidative stress having antigonadotropic and
antisteroidogenic actions. Melatonin is a regulator of seasonal reproduction in photoperiodic
species and highly effective antioxidant and free radical scavenger. Therefore, a study
was designed to evaluate the effect of sustained-release melatonin on biomarkers of
oxidative stress i.e., the serum malondialdehyde (MDA) and nitric oxide (NO), and the total
antioxidant capacity (TAC). For the study, postpartum buffaloes diagnosed as summer
anestrus (absence of overt signs of estrus, concurrent rectal examination, and RIA for serum
progesterone) were grouped as treated (single subcutaneous injection of melatonin at
18 mg/50 kg body weight dissolved in sterilized corn oil as vehicle, n ¼ 20) and untreated
(subcutaneous sterilized corn oil, n ¼ 8). Blood sampling for estimation of serum TAC and
MDA (mmol/L) and NO (mmol/L) was carried out at 4 days of interval from 8 days before
treatment till 28 days after treatment or for the ensuing entire cycle length. Results showed
serum TAC concentration was higher in the treatment group with a significant (P < 0.05)
increasing trend, whereasMDA and NO revealed a significant (P
Not Available
 
Date 2021-09-29T10:12:39Z
2021-09-29T10:12:39Z
2015-01-01
 
Type Research Paper
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/64804
 
Language English
 
Relation Not Available;
 
Publisher Not Available