Sustained delivery of exogenous melatonin influences biomarkers of oxidative stress and total antioxidant capacity in summer stressed anoestrous water buffalo (Bubalus bubalis)
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Title |
Sustained delivery of exogenous melatonin influences biomarkers of oxidative stress and total antioxidant capacity in summer stressed anoestrous water buffalo (Bubalus bubalis)
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Creator |
Kumar A
Mehrotra S Singh G Narayanan K Das GK Soni YK MAHAK SINGH Mahla AS Srivastava N |
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Subject |
Malondialdehyde
Nitric oxide Oxidative stress Free radical Reactive oxygen species |
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Description |
Not Available
High ambient temperature during summer in tropical and subtropical countries predisposes water buffaloes (Bubalus bubalis) to develop oxidative stress having antigonadotropic and antisteroidogenic actions. Melatonin is a regulator of seasonal reproduction in photoperiodic species and highly effective antioxidant and free radical scavenger. Therefore, a study was designed to evaluate the effect of sustained-release melatonin on biomarkers of oxidative stress i.e., the serum malondialdehyde (MDA) and nitric oxide (NO), and the total antioxidant capacity (TAC). For the study, postpartum buffaloes diagnosed as summer anestrus (absence of overt signs of estrus, concurrent rectal examination, and RIA for serum progesterone) were grouped as treated (single subcutaneous injection of melatonin at 18 mg/50 kg body weight dissolved in sterilized corn oil as vehicle, n ¼ 20) and untreated (subcutaneous sterilized corn oil, n ¼ 8). Blood sampling for estimation of serum TAC and MDA (mmol/L) and NO (mmol/L) was carried out at 4 days of interval from 8 days before treatment till 28 days after treatment or for the ensuing entire cycle length. Results showed serum TAC concentration was higher in the treatment group with a significant (P < 0.05) increasing trend, whereasMDA and NO revealed a significant (P Not Available |
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Date |
2021-09-29T10:12:39Z
2021-09-29T10:12:39Z 2015-01-01 |
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Type |
Research Paper
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Identifier |
Not Available
Not Available http://krishi.icar.gov.in/jspui/handle/123456789/64804 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Not Available
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