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Efficient synthesis of hydroxystyrenes via biocatalytic decarboxylation/deacetylation of substituted cinnamic acids by newly isolated Pantoea agglomerans strains

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Title Efficient synthesis of hydroxystyrenes via biocatalytic decarboxylation/deacetylation of substituted cinnamic acids by newly isolated Pantoea agglomerans strains
 
Creator Upendra K Sharma
Nandini Sharma
Richa Salwan
Rakesh Kumar
Ramesh C Kasana
Arun K Sinha
 
Subject decarboxylation
deacetylation
hydroxystyrenes
Pantoea agglomerans
cinnamic acids
 
Description Not Available
BACKGROUND: Decarboxylation of substituted cinnamic acids is a predominantly followed pathway for obtaining hydroxystyrenes – one of the most extensively explored bioactive compounds in the food and flavor industry (e.g. FEMA GRAS approved 4-vinylguaiacol). For this, mild and green strategies providing good yields with high product selectivity are needed.
RESULTS: Two newly isolated bacterial strains, i.e. Pantoea agglomerans KJLPB4 and P. agglomerans KJPB2, are reported for mild and effective decarboxylation of substituted cinnamic acids into corresponding hydroxystyrenes. Key operational parameters
for the process, such as incubation temperature, incubation time, substrate concentration and effect of co-solvent, were optimized using ferulic acid as a model substrate. With strain KJLPB4, 1.51 g L−1 4-vinyl guaiacol (98% yield) was selectively obtained from 2 g L−1 ferulic acid at 28 ◦C after 48 h incubation. However, KJPB2 provided vanillic acid in 85% yield after 72 h following the oxidative decarboxylation pathway. In addition, KJLPB4 was effectively exploited for the deacetylation of acetylated α-phenylcinnamic acids, providing corresponding compounds in 65–95% yields.
CONCLUSION: Two newly isolated microbial strains are reported for the mild and selective decarboxylation of substituted cinnamic acids into hydroxystyrenes. Preparative-scale synthesis of vinyl guaiacol and utilization of renewable feedstock (ferulic acid extracted from maize bran) have been demonstrated to enhance the practical utility of the process.
Not Available
 
Date 2019-05-02T04:35:56Z
2019-05-02T04:35:56Z
2011-09-14
 
Type Research Paper
 
Identifier 5
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/19111
 
Language English
 
Relation Not Available;
 
Publisher Wiley