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Modulatory effects of <em>Saccharomyces cerevisiae</em> var. boulardii on experimentally induced benign prostatic hyperplasia in rats

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Title Statement Modulatory effects of <em>Saccharomyces cerevisiae</em> var. boulardii on experimentally induced benign prostatic hyperplasia in rats
 
Added Entry - Uncontrolled Name Onoja, Remigius Ibe; University of Nigeria, Nsukka
Joshua, Parker Elijah; University of Nigeria, Nsukka
Obidah, Wilson ; Modibbo Adama University of Technology Yola, Yola, Nigeria
Onyekaba, Alloysius Chibuzor; University of Nigeria, Nsukka
Mgbeahurike, Anthony Christian; University of Nigeria, Nsukka
Emesiani, Benjamin Ifechukwu; University of Nigeria, Nsukka
 
Uncontrolled Index Term Dihydrotestosterone; Probiotic; Prostate gland; Rodents; Testosterone propionate; Yeast
 
Summary, etc. Benign prostatic hyperplasia (BPH) is an age-related non-neoplastic disease of the prostate gland in men that has become a global health issue in recent years. Due to the side effects of conventional treatment options, attention is now focused on phytotherapeutics for its management. We investigated the possible protective effect of Saccharomyces cerevisiae var. boulardii in a rat model of testosterone propionate (TP) induced BPH. Rats were divided into five groups: Gr. I, untreated control group; Gr. II, TP group; Gr. III, TP + finasteride; Gr. IV, TP + S. cerevisiae var. boulardii; and Gr. V, S. cerevisiae var. boulardii group. Treatments were given daily for 28 days. At the end of the experiment, all rats were weighed and the prostatic indices, prostate specific antigen, serum testosterone concentration as well as the histological and histomorphometric changes were evaluated. Saccharomyces cerevisiae var. boulardii significantly (P &lt;0.05) reduced prostate weight, prostatic index, serum prostate specific antigen, prostatic epithelial thickness and increased luminal diameter. Thus, the results of this study suggest that S. cerevisiae var. boulardii is a potential pharmacological candidate for management of benign prostatic hyperplasia.
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2022-12-26 14:38:15
 
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http://op.niscair.res.in/index.php/IJEB/article/view/59740
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 61, ##issue.no## 01 (2023): IJEB [JANUARY 2023]
 
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