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Antifertility activity of <em>Oroxylum indicum</em> (L.) Kurz:<em>In vitro</em> and <em>in vivo</em> study on human sperm and male wistar rats

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Title Statement Antifertility activity of <em>Oroxylum indicum</em> (L.) Kurz:<em>In vitro</em> and <em>in vivo</em> study on human sperm and male wistar rats
 
Added Entry - Uncontrolled Name Das, Banani ; Assam University, Silchar, India -788011
Roy, Kalyan ; Himalayan Pharmacy Institute. Majhitar. Rangpo, Sikkim-737136, India
Talukdar, Anupam Das; Assam University, Silchar, India -788011
Dey, Amitabha ; Institute of Bioresources and Sustainable Development (IBSD), An autonomous Institute of Department of Biotechnology, Government of India, Takyelpat, Imphal, Manipur. 795001
Nongalleima, Khumukcham ; Institute of Bioresources and Sustainable Development (IBSD), An autonomous Institute of Department of Biotechnology, Government of India, Takyelpat, Imphal, Manipur. 795001
Das, Supriya ; Institute of Pharmacy, Harish Chandra PG College, Varanasi, Uttar Pradesh-221002.
Sharma, Prasanti
Choudhury, Manabendra Dutta; Assam University, Silchar, India -788011
Deb, Lokesh ; Institute of Bioresources and Sustainable Development - Sikkim Centre (Department of Biotechnology, Government of India),
Department of Biotechnology - Institute of Bioresources and Sustainable Development (IBSD), Government of India, Imphal, Manipur
 
Uncontrolled Index Term Baicalin; Broken bones tree; Contraceptive; Indian trumpet flower; Kampong; Oroxylin; Sperm motility; Testosterone
 
Summary, etc. Oroxylum indicum (L.) Kurz, commonly called as Broken bones tree or Indian trumpet flower, belonging to Fam. Bignoniaceae, is traditionally used as a contraceptive by ethnic people of Tripura, North-East India. Here, we investigated the scientific basis for use of O. indicum as male antifertility agent by folklore healers. In vitro spermicidal activity of aqueous (AEOI) and methanolic (MEOI) extracts of O. indicum stem bark were studied on human sperm. The in vivo activity was experimented on male albino rats. The treated animals were allowed to mate and the pups delivered by female rat partners were counted. Phytochemical estimation of test samples was done using HPLC. The AEOI and MEOI treatments significantly decreased human sperm motility and viability. Test extracts have increased the hypo-osmotic swelling of sperm. Both the extracts were significantly declined the weight of reproductive organ. The MEOI treated rats have shown significant decrease in sperm motility and sperm counts. AEOI and MEOI treatment significantly reduced level of testosterone, but sharply raised dihydrotestosterone and prostaglandin in rats. Results testified the traditional claim for use of O. indicum as a male contraceptive agent, where MEOI have shown reversible action on male reproductive system leading to contraception without harming the libido.
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2022-12-26 14:38:15
 
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http://op.niscair.res.in/index.php/IJEB/article/view/45656
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 61, ##issue.no## 01 (2023): IJEB [JANUARY 2023]
 
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