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Whole-genome resequencing of Dorper and Hu sheep to reveal selection signatures associated with important traits

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Title Whole-genome resequencing of Dorper and Hu sheep to reveal selection signatures associated with important traits
 
Creator Lv, Xiaoyang
 
Contributor Chen, Weihao
Wang, Shanhe
Cao, Xiukai
Yuan, Zehu
Getachew, Tesfaye
Mwacharo, Joram
Haile, Aynalem
Sun, Wei
 
Subject no poverty
poverty reduction, livelihoods and jobs
selective signal analysis
population differentiation
cross population extended haplotype homozygosity
 
Description Dorper and Hu sheep exhibit different characteristics in terms of reproduction, growth, and meat quality. Comparison of the genomes of two breeds help to reveal important genomic information. In this study, whole genome resequencing of 30 individuals (Dorper, DB and Hu sheep, HY) identified 15,108,125 single nucleotide polymorphisms (SNPs). Population differentiation (Fst) and cross population extended haplotype homozygosity (XP-EHH) were performed for selective signal analysis. In total, 106 and 515 overlapped genes were present in both the Fst results and XP-EHH results in HY vs DB and in DB vs HY, respectively. In HY vs DB, 106 genes were enriched in 12 GO terms and 83 KEGG pathways, such as ATP binding (GO:0005524) and PI3K-Akt signaling pathway (oas04151). In DB vs HY, 515 genes were enriched in 109 GO terms and 215 KEGG pathways, such as skeletal muscle cell differentiation (GO:0035914) and MAPK signaling pathway (oas04010). According to the annotation results, we identified a series of candidate genes associated with reproduction (UNC5C, BMPR1B, and GLIS1), meat quality (MECOM, MEF2C, and MYF6), and immunity (GMDS, GALK1, and ITGB4). Our investigation has uncovered genomic information for important traits in sheep and provided a basis for subsequent studies of related traits.
 
Date 2022-10-06
2023-01-03T22:05:41Z
2023-01-03T22:05:41Z
 
Type Journal Article
 
Identifier https://mel.cgiar.org/dspace/limited
Xiaoyang Lv, Weihao Chen, Shanhe Wang, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Joram Mwacharo, Aynalem Haile, Wei Sun. (6/10/2022). Whole-genome resequencing of Dorper and Hu sheep to reveal selection signatures associated with important traits. Animal Biotechnology.
https://hdl.handle.net/20.500.11766/67861
Timeless limited access
 
Language en
 
Publisher Taylor and Francis Group
 
Source Animal Biotechnology;(2022)