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Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes

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Title Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes
 
Creator Gardner, M.J.
Bishop, Richard P.
Shah, Tushaar
Villiers, Etienne P. de
Carlton, J.M.
Hall, N.
Ren, Q.
Paulsen, I.T.
Pain, A.
Berriman, M.
Wilson, R.J.M.
Sato, S.
Ralph, S.A.
Mann, D.J.
Xiong, Z.
Shallom, S.J.
Weidman, J.
Jiang, L.
Lynn,, J.
Weaver, B.
Shoaibi, A.
Domingo, A.R.
Wasawo, D.
Crabtree, J.
Wortman, J.R.
Haas, B.
Angiuoli, S.V.
Creasy, T.H.
Lu, C.
Suh, B.
Silva, Joana C.
Utterback, T.R.
Feldblyum, T.V.
Pertea, M.
Allen, J.
Nierman, W.C.
Taracha, E.L.N.
Salzberg, S.L.
White, O.R.
Fitzhugh, H.A.
Morzaria, S.P.
Venter, J. Craig
Fraser, C.M.
Nene, Vishvanath
 
Subject theileria parva
bovinae
genomes
nucleotide sequence
lymphocytes
cell mediated immunity
pathogens
small farms
plasmodium falciparum
chromosomes
dna
 
Description We report the genome sequence of Theileria parva, an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum, and its plastid-like genome represents the first example where all apicoplast genes are encoded on one DNA strand. We tentatively identify proteins that facilitate parasite segregation during host cell cytokinesis and contribute to persistent infection of transformed host cells. Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated.
 
Date 2005
2013-07-03T05:26:09Z
2013-07-03T05:26:09Z
 
Type Journal Article
 
Identifier Science;309(5731): 134-137
0036-8075
https://hdl.handle.net/10568/33167
https://doi.org/10.1126/science.1110439
 
Language en
 
Rights Open Access
 
Format p. 134-137
 
Source Science