Record Details

Genome of the host-cell transforming parasite Theileria annulata compared with T. parva

CGSpace

View Archive Info
 
 
Field Value
 
Title Genome of the host-cell transforming parasite Theileria annulata compared with T. parva
 
Creator Pain, A.
Renauld, H.
Berriman, M.
Murphy, L.
Yeats, C.A.
Weir, W.
Kerhornou, A.
Aslett, M.
Bishop, Richard P.
Bouchier, C.
Cochet, M.
Coulson, R.M.R.
Cronin, A.
Villiers, Etienne P. de
Fraser, A.
Fosker, N.
Gardner, M.
Goble, A.
Griffiths-Jones, S.
Harris, D.E.
Katzer, F.
Larke, N.
Lord, A.
Maser, P.
McKellar, S.
Mooney, P.
Morton, F.
Nene, Vishvanath
O'Neil, S.
Price, C.
Quail, M.A.
Rabbinowitsch, E.
Rawlings, N.D.
Rutter, S.
Saunders, D.
Seeger, K.
Shah, Tushaar
Squares, R.
Squares, S.
Tivey, A.
Walker, A.R.
Woodward, J.
Dobbelaere, D.A.E.
Langsley, G.
Rajandream, M.A.
McKeever, Declan J.
Shiels, B.
Tait, A.
Barrell, B.
Hall, N.
 
Subject theileria annulata
theileria parva
genome
hosts
cell
 
Description Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria-specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.
 
Date 2005
2013-07-03T05:26:09Z
2013-07-03T05:26:09Z
 
Type Journal Article
 
Identifier Science;309(5731): 131-133
0036-8075
https://hdl.handle.net/10568/33166
https://doi.org/10.1126/science.1110418
 
Language en
 
Rights Open Access
 
Format p. 131-133
 
Source Science