Record Details

A novel coronavirus and a broad range of viruses in Kenyan cave bats

CGSpace

View Archive Info
 
 
Field Value
 
Title A novel coronavirus and a broad range of viruses in Kenyan cave bats
 
Creator Kamau, J.
Ergunay, K.
Webala, P.W.
Justi, S.A.
Bourke, B.P.
Kamau, M.W.
Hassell, James M.
Chege, M.N.
Mwaura, D.K.
Simiyu, C.
Kibiwot, S.
Onyuok, S.
Caicedo-Quiroga, L.
Li, T.
Zimmerman, D.M.
Linton, Y.M.
 
Subject coronavirinae
chiroptera
viruses
biodiversity
health
 
Description Background and Methods: To investigate virus diversity in hot zones of probable pathogen spillover, 54 oral-fecal swabs were processed from five bat species collected from three cave systems in Kenya, using metagenome sequencing. Results: Viruses belonging to the Astroviridae, Circoviridae, Coronaviridae, Dicistroviridae, Herpesviridae and Retroviridae were detected, with unclassified viruses. Retroviral sequences were prevalent; 74.1% of all samples were positive, with distinct correlations between virus, site and host bat species. Detected retroviruses comprised Myotis myotis, Myotis ricketti, Myotis daubentonii and Galidia endogenous retroviruses, murine leukemia virus-related virus and Rhinolophus ferrumequinum retrovirus (RFRV). A near-complete genome of a local RFRV strain with identical genome organization and 2.8% nucleotide divergence from the prototype isolate was characterized. Bat coronavirus sequences were detected with a prevalence of 24.1%, where analyses on the ORF1ab region revealed a novel alphacoronavirus lineage. Astrovirus sequences were detected in 25.9%of all samples, with considerable diversity. In 9.2% of the samples, other viruses including Actinidia yellowing virus 2, bat betaherpesvirus, Bole tick virus 4, Cyclovirus and Rhopalosiphum padi virus were identified. Conclusions: Further monitoring of bats across Kenya is essential to facilitate early recognition of possibly emergent zoonotic viruses.
 
Date 2022-12-17
2022-12-27T07:07:11Z
2022-12-27T07:07:11Z
 
Type Journal Article
 
Identifier Kamau, J., Ergunay, K., Webala, P.W., Justi, S.A., Bourke, B.P., Kamau, M.W., Hassell, J., Chege, M.N., Mwaura, D.K., Simiyu, C., Kibiwot, S., Onyuok, S., Caicedo-Quiroga, L., Li, T., Zimmerman, D.M. and Linton, Y.M. 2022. A novel coronavirus and a broad range of viruses in Kenyan cave bats. Viruses 14(12): 2820.
1999-4915
https://hdl.handle.net/10568/126312
https://doi.org/10.3390/v14122820
 
Language en
 
Rights CC-BY-4.0
Open Access
 
Format 2820
 
Source Viruses