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Anticancer potential of <em>Solanum lycopersicum</em> L. extract in human lung epithelial cancer cells A549

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Title Statement Anticancer potential of <em>Solanum lycopersicum</em> L. extract in human lung epithelial cancer cells A549
 
Added Entry - Uncontrolled Name Sathelly, Krishnamurthy
Kumar Kalagatur, Naveen
Kiranmayi Mangamuri, Usha
Obul Reddy Puli, Chandra
Poda, Sudhakar
 
Uncontrolled Index Term Anticancer activity; Antioxidant activity; Apoptosis; LDH assay; Live/dead dual staining; MTT assay; Solanum lycopersicum L.
 
Summary, etc. The study aimed to reveal the phytochemical profile, free radical scavenging potential, and anticancer activity of <em>Solanum lycopersicum</em> L. leaf extract (SLLE). According to the study, SLLE contains plant secondary metabolites that are beneficial for health, like phenolics, flavonoids, ascorbic acid, alkaloids, and terpenoids. The SLLE has shown potential free radical scavenging potential in DPPH and ABTS free radical scavenging analysis and its EC50 values (concentration required to inhibit 50% of free radicals) were determined as 481.29 ± 33.82 and 527.56 ± 20.34 µg/mL, respectively. The SLLE has the ability to scavenge free radicals and could be used to treat illnesses brought on by oxidative stress. The anticancer activity of SLLE was assessed by MTT, LDH, micro-morphological, live/dead dual staining, and caspase-3 analysis. In the MTT assay, the IC50 value (concentration required to inhibit 50% of cell viability) of SLLE was determined as 190.41 ± 4.77 µg/mL. Furthermore, SLLE has shown potential anticancer activity by adversely affecting the plasma membrane integrity and escalating the caspase-3 levels. In the biomedical field, SLLE could be highly useful to treat cancer.
 
Publication, Distribution, Etc. Indian Journal of Biochemistry and Biophysics (IJBB)
2023-01-06 16:57:39
 
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http://op.niscair.res.in/index.php/IJBB/article/view/69519
 
Data Source Entry Indian Journal of Biochemistry and Biophysics (IJBB); IJBB Vol. 60 (1) [January 2023]
 
Language Note en