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Moringa oleifera seeds attenuate benzene-induced alterations in lipid peroxidation and antioxidant enzymes in liver and kidney tissues of Wistar rats

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Title Moringa oleifera seeds attenuate benzene-induced alterations in lipid peroxidation and antioxidant enzymes in liver and kidney tissues of Wistar rats
 
Creator Rajkumar, R
Ilango, B
Vinothkumar, K
Savidha, R
Senthilkumar, S
Ezhilarasan, D
Sukumar, E
 
Subject Animal model
Chemical toxicity
Enzymes
Histopathology
Lipid peroxidation
Moringa seeds
 
Description 26-30
Benzene is a notorious toxicant that is responsible for a host of diseases including leukemia. Its concentration in the
environment is increasing day-by-day due to excessive automobile use, accelerated industrial activities and cigarette smoke.
The awareness on the harmful effects of benzene on health is limited and no antidote has been reported yet. In this study, an
attempt has been made to find out a suitable remedy to overcome benzene toxicity in a living organism from a natural source
with the seeds of the plant Moringa oleifera (MO). Thirty six Wistar rats were considered for the study and divided into six
groups (n=6). While group I remained as control with normal animals, those in groups II – VI received benzene by oral
route (800 mg/kg body weight) for 28 consecutive days. On day 29, the benzene-treated animals in groups III – VI received
respectively the standard drug ascorbic acid (AA, 25 mg/kg body weight) and MO (50, 100 and 200 mg/kg body weight) for
the following 7 days. Group II rats that received only benzene served as negative control without any treatment. On day 36,
all the animals were sacrificed and vital organs liver and kidney were removed for studying lipid peroxidation (LPO) and
antioxidant markers [Superoxide dismutase (SOD), Total reduced glutathione (TRG), Glutathione peroxidase (GPx) and
Catalase (CAT)] in addition to histopathological changes in the tissues. The results of the study revealed that significant
changes occurred in the above parameters due to benzene dosing to animals were reverted to near normal values on MO
administration in the liver and kidney tissues as compared to untreated animals, suggesting MO’s pro-active role in
attenuating benzene toxicity.
 
Date 2023-01-10T10:58:51Z
2023-01-10T10:58:51Z
2023-01
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/61190
https://doi.org/10.56042/ijbb.v60i1.55819
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJBB Vol.60(01) [January 2023]