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Pharmacokinetics of suramin in uninfected and experimental Trypanosoma evansi infected buffalo calves

Indian Agricultural Research Journals

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Title Pharmacokinetics of suramin in uninfected and experimental Trypanosoma evansi infected buffalo calves
 
Creator Puril, Uk
Sharma, Sk
Kaur, Paramjit
Juyal, P D
 
Subject Calves, Pharmacokinetics; Suramin; Trypanosoma evansi
 
Description The kinetic pattern ofsuramin was studied in uninfected and experimental Trypanosoma evansi infected (4.06 x 107 trypanosomes calf) in buffalo calves. The course of infection was chronic in experimental Tevansi infected buffalo calves and the infection was diagnosed by mice sub-inoculation test. The plasma level of suramin was 103.8± 1.63 and 160.5 ± 3.60 flg/ml at 1 min which declined to 8.29 ± 0.19 and 10.9 ± 0.88 Ilg/ml at 7 day in infected and uninfected buffalo calves, respectively, when suramin was administered @0.5 g/45 kg body weight. However, no concentration of the drug was found in plasma after 7 days post treatment. The pharmacokinetics ofsuramin following ilv administration was calculated by 3-compartmental open model. There was significant lower plasma levels up to 6 h and lower values of oc2 AUC and CP in infected than uninfected buffalo calves. 
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2011-02-09
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/4046
 
Source The Indian Journal of Animal Sciences; Vol 76, No 7 (2006)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/4046/1630
 
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