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Genes responsible for cancer: a review

Indian Agricultural Research Journals

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Title Genes responsible for cancer: a review
 
Creator Pawaiya, Rajveer Singh
Krishna, Lal
Kumar, Ram
 
Subject Animal cancer, oncogene, protooncogene, tumour suppressor gene, microRNA, review
 
Description Cancer is a complex disease where dynamic changes in multiple genes essential for diverse molecular pathways are involved in its initiation, progression, invasion and metastasis. The genes implicated in cancer include those involved in cell cycle control, apoptosis, DNA repair, ageing and immortalization, angiogenesis and metastasis. Activation of oncogenes, inactivation of tumour suppressor genes and alterations in microRNA and other genes through sequential accumulation of mutations, combined with multiple cycles of clonal selection and evolution, facilitate the process of carcinogenesis. Disruption of about six to twelve cellular processes is required for neoplastic transformation of a cell. Many oncogenes and oncoproteins are being used as ‘tumour markers’ and ‘targets’ for cancer diagnosis, prognosis and therapy as also for the development of new anticancer drugs. In the oncology research riding on the technological advances in genomics and proteomics has resulted in the generation of molecular portraits of various cancers in individuals, thus facilitating to provide individualistic treatment options. Considerable progress has been made in producing small molecules capable of inhibiting the enzymatic activity of Abl, Kit, EGFR, and ErbB2. For cases in which the oncogene products are not enzymes, it has been much more difficult to develop new agents. The discovery of the involvement of microRNAs in the initiation and progression of human cancer may provide additional targets for anticancer treatments.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor Indian Veterinary Research Institute, ICAR
 
Date 2011-04-15
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Review Article
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/4532
 
Source The Indian Journal of Animal Sciences; Vol 81, No 8 (2011)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/4532/3934
 
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