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Efficacy of vaccines prepared from Pasteurella multocida cells grown in chemically defined media

Indian Agricultural Research Journals

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Title Efficacy of vaccines prepared from Pasteurella multocida cells grown in chemically defined media
 
Creator SRIVASTAVA, S K
 
Subject Heamorrhagic septicaemia, Outer membrane protein, Pasteurella Multocida Vaccme
 
Description Pasteurella multocida serotype B: 2 was grown in chemically defined medium (COM), COM supplemented with iron (CDM.Fe) and brain heart infusion broth (BHIB) and studied for their imrnunogenicity. Cells grown in CDM expressed maximum outer membrane protein (OMP) as demonstrated by congo red binding property of the bacterial cells. These cells, when used as vaccine, afforded maximum protection (100%) in mice than cells grown in the CDM.Pe (78%) or BRIB (72%). In buffalo calves the CDM.Fe and BHIB grown cell vaccine elicited higher anti-protein passive haemagglutination antibody responses than the COM vaccine. Cells grown in COM. Fe were more agglutinogenic than the CDM or BHIB grown cells. The study suggested that P.multocida cells grown in COM or CDM.Fe media possessed different antigens resulting in higher seroreactivity.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2013-12-12
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/35552
 
Source The Indian Journal of Animal Sciences; Vol 70, No 2 (2000)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/35552/15701
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences