Record Details

Pharmacokinetics, urinary excretion and dosage regimen of ceftriaxone in crossbred cow calves following single intramuscular administration

Indian Agricultural Research Journals

View Archive Info
 
 
Field Value
 
Title Pharmacokinetics, urinary excretion and dosage regimen of ceftriaxone in crossbred cow calves following single intramuscular administration
 
Creator Johal, Bindu
Srivastava, A K
 
Subject Ceftiraxone; Crossbred cow calves; Dosage regimen; Pharmacokinetics; Urinary excretion
 
Description The pharmacokinetics and urinary excretion of ceftriaxone after I/M administration were investigated in healthy cow calves. Following single intramuscular administration of ceftriaxone (10 mg.kg-1), appreciable concentration (0.69 ± 0.08 g.ml-1) of drug was measured at 1 min and the peak plasma level (18.8 ± 0.68 g.ml-1) was achieved at 30 min. The absorption and elimination half lives were 0.050 ± 0.018 hr and 6.54 ± 0.87 hr respectively. The apparent volume of distribution and total body clearance were 3.19 ± 0.42 litre kg-1 and 0.34 ± 0.02 litre kg-1.hr-1 respectively. Approximately 30% of total administered dose was eliminated in urine within 24 hr of its administration. On the basis of pharmacokinetic parameters, a satisfactory intramuscular dosage regimen of ceftriaxone in cattle was calculated to be 11 mg.kg-1) repeated at 30 hr intervals.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2012-07-25
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/22304
 
Source The Indian Journal of Animal Sciences; Vol 68, No 10 (1998)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/22304/10962
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences