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Characterization and association of the Pit-1 gene in the Indian buffalo

Indian Agricultural Research Journals

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Title Characterization and association of the Pit-1 gene in the Indian buffalo
 
Creator PARIKH, RAKESH C
RANK, DHARMSHIBHAI N
 
Subject Association, Indian Buffalo, Milk yield, Pit-1 gene, SNP
 
Description Pituitary-specific transcription factor (Pit-1) is responsible for pituitary development and hormone expression in mammals. In present study, a comparison of buffalo Pit-1 gene sequences with Bos taurus revealed no nucleotide changes however, 7 single nucleotide polymorphisms (SNPs), one of which was non-synonymous were found within Indian buffalo breeds (Bubalus bubalis). SNP c.160 T>A alters the encoded amino acid from methionine to lysine. Association of all SNPs with milk production traits was assessed in Mehsana buffalo populations and the results demonstrated that SNP c.160 T>A was significantly associated with the milk fat percentage (P=0.0358). Sequence analysis showed that the buffalo Pit-1 protein shares high homology with cattle (Bos taurus) (100%), goat (99%), sheep (99%), human (96%) and pig (98%). Polymorphisms detected in buffalo Pit-1 gene are expected to have functional significance and might be useful as genetic markers in association studies for milk fat and milk yield in buffalo.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2013-12-19
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/35802
 
Source The Indian Journal of Animal Sciences; Vol 83, No 12 (2013)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/35802/15845
 
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