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Anti-inflammatory decurrencyclics A-B, two undescribed nor-dammarane triterpenes from triangular sea bell Turbinaria decurrens

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Relation http://eprints.cmfri.org.in/15999/
https://www.tandfonline.com/doi/full/10.1080/14786419.2022.2087182
https://doi.org/10.1080/14786419.2022.2087182.
 
Title Anti-inflammatory decurrencyclics A-B, two undescribed nor-dammarane triterpenes from triangular sea bell Turbinaria decurrens
 
Creator Thambi, Anjaly
Chakraborty, Kajal
 
Subject Algal nutrition
Biochemical composition
Biochemistry
Algae
 
Description Intertidal triangular sea bell Turbinaria decurrens (Bory de Saint-Vincent) (family Sargassaceae) belongs to one of the largely abundant genus of marine brown alga. Bioactivity-directed chromatographic purification of the organic extract of T. decurrens afforded two new nor-dammarane triterpenoids named as decurrencyclic A-B. Decurrencyclic B showed superior attenuation properties against cyclooxygenase-2 (IC50 13.98 μM) and 5-lipoxygenase (IC50 3.02 μM) in contrast with decurrencyclic A. Decurrencyclic B showed higher inhibition potential against COX-2 than that revealed by the anti-inflammatory agent, ibuprofen (IC50 70.44 μM). The higher selectivity index of decurrencyclics (1.39–1.57) acknowledged their selective attenuation property against inducible cyclooxygenase-2. In-silico molecular modeling analysis of decurrencyclic B with the inflammatory enzymes showed least binding energy of −14.55 kcal mol−1. These reports have proven that decurrencyclic B could be a potential therapeutic lead for use against inflammatory pathogenesis.
 
Publisher Taylor and Francis
 
Date 2022
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/15999/1/Natural%20Product%20Research_2022_Kajal%20Chakraborty.pdf
Thambi, Anjaly and Chakraborty, Kajal (2022) Anti-inflammatory decurrencyclics A-B, two undescribed nor-dammarane triterpenes from triangular sea bell Turbinaria decurrens. Natural Product Research. pp. 1-12. ISSN 1478-6427 (Online)