Record Details

Marginolides A-B, polyether macrolide analogues from veined octopus Amphioctopus marginatus: anti-hypertensive leads attenuate angiotensin converting enzyme

CMFRI Repository

View Archive Info
 
 
Field Value
 
Relation http://eprints.cmfri.org.in/15630/
https://www.tandfonline.com/doi/full/10.1080/14786419.2021.2013841
doi.org/10.1080/14786419.2021.2013841
 
Title Marginolides A-B, polyether macrolide analogues from veined octopus Amphioctopus marginatus: anti-hypertensive leads attenuate angiotensin converting enzyme
 
Creator Chakraborty, Kajal
Shilpa, K P
 
Subject Cephalopods
Molluscan Fisheries
 
Description Angiotensin-I-converting enzyme (ACE) is considered as a major drug target for the treatment of hypertension as it catalyses the production of vasoconstrictor angiotensin II from angiotensin I. ACE inhibitor agents are an effective therapeutic strategy to control high blood pressure. Unprecedented polyether macrolides, marginolide A and B were isolated from the crude extract of marine octopus, Amphioctopus marginatus via bioassay-directed sequential chromatographic fractionation. Marginolide A displayed
considerably greater ACE attenuation potential (IC50 0.58 mM) than that exhibited by marginolide B (IC50 0.72 mM). Higher antioxidant properties of marginolide A against the oxidant species (IC50 1 mM) also supported its potential ACE inhibitory activity. Higher polar characteristics along with acceptable hydrophobichydrophilic equilibrium (partition coefficient of octanol-water, log Pow 2–4) revealed the potential anti-hypertensive activities of marginolides. This study recognized the anti-hypertensive properties of marginolides as promising pharmaceutical leads.
 
Publisher Taylor and Francis
 
Date 2021
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/15630/1/Natural%20Product%20Research_2021_Kajal%20Chakraborty%20and%20Shilpa%20K%20P.pdf
Chakraborty, Kajal and Shilpa, K P (2021) Marginolides A-B, polyether macrolide analogues from veined octopus Amphioctopus marginatus: anti-hypertensive leads attenuate angiotensin converting enzyme. Natural Product Research. pp. 1-13.