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Novel anti-hyperglycemic sulfated pyruvylated polysaccharide from marine macroalga Hydropuntia edulis

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Relation http://eprints.cmfri.org.in/16449/
https://www.tandfonline.com/doi/abs/10.1080/14786419.2022.2140660?journalCode=gnpl20
https://doi.org/10.1080/14786419.2022.2140660
 
Title Novel anti-hyperglycemic sulfated pyruvylated polysaccharide from marine macroalga Hydropuntia edulis
 
Creator Thambi, Anjaly
Chakraborty, Kajal
 
Subject Bioactive compounds
Algae
 
Description Dipeptidyl peptidase is a crucial enzyme that regulates glucose

metabolism by degrading incretins, such as glucagon-like-pep-
tide-1, thereby reducing insulin secretion from the pancreatic

b-cells. Consequently, dipeptidyl peptidase-IV inhibitors are an
important remedial approach to moderate the hyperglycemic
pathophysiology. A pyruvylated polysaccharide characterized as
[!3)-4,6-O-(1-carboxyethylidene)-b-D-galp-(2SO3

)-(1!4)-3,6-a-L-
AnGalp-(2OMe)-(1!], isolated from the marine macroalga

Hydropuntia edulis, showed attenuation potential against dipep-
tidyl peptidase-IV (IC50 4.44 lM). The structure was elucidated

using mass and one/two-dimensional nuclear magnetic resonance
spectroscopic analyses of hydrolyzed polysaccharide besides

glycosidic linkages obtained from partially methylated alditol acet-
ate derivative. The isolated polysaccharide also revealed potential

anti-carbolytic properties against a-amylase/a-glucosidase (IC50

45–47 lM). The results proved the candidacy of pyruvylated poly-
saccharide isolated from H. edulis as a potential therapeutic lead

against hyperglycemia.
 
Publisher Taylor and Francis
 
Date 2022
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/16449/1/Natural%20Product%20Research_2022_Kajal%20Chakraborty_Anti%20hyperglycemic%20sulfated%20pyruvylated%20polysaccharide_Hydropuntia%20edulis.pdf
Thambi, Anjaly and Chakraborty, Kajal (2022) Novel anti-hyperglycemic sulfated pyruvylated polysaccharide from marine macroalga Hydropuntia edulis. Natural Product Research. pp. 1-13. ISSN 1478-6427 (Online)