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Antioxidative oxygenated terpenoids with bioactivities against pro-inflammatory inducible enzymes from Indian squid, Uroteuthis (Photololigo) duvaucelii

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Relation http://eprints.cmfri.org.in/14948/
https://www.tandfonline.com/doi/abs/10.1080/14786419.2019.1610957?journalCode=gnpl20
https://doi.org/10.1080/14786419.2019.1610957
 
Title Antioxidative oxygenated terpenoids with bioactivities against pro-inflammatory inducible enzymes from Indian squid, Uroteuthis (Photololigo) duvaucelii
 
Creator Chakraborty, Kajal
Krishnan, Soumya
Joy, Minju
 
Subject Bioprospecting
Bioactive compounds
Biochemistry
Cephalopods
 
Description Cephalopod squid, Uroteuthis (Photololigo) duvaucelii is consumed as culinary delicacy along the southwest part of Asian continent. Ethyl acetate:methanol extract of U. duvaucelii was chromatographically fractionated to yield C19 furano-norditerpenoid (1) along with irregular C15 sesquiterpenoid (2) and C20 diterpenoid compounds (3). In vitro anti-inflammatory and antioxidant analyses were utilised to evaluate their bio-potentials. The C19 furano-norditerpenoid was reported for significantly effective 2,2-diphenyl-1-picrylhydrazyl radical inhibition (IC50 0.60 mg/mL) than other compounds and α-tocopherol (IC50 ≥ 0.64 mg/mL). The 2,2’-azino-bis-3-ethylbenzothiozoline-6-sulfonic acid inhibition and ferrous ion chelating potentials were higher for compounds 1 and 2 (IC50 ∼ 0.69 and ∼0.84 mg/mL, respectively) compared to α-tocopherol (IC50 0.76–0.95 mg/mL). The studied compounds displayed comparable inhibitory activities with synthetic ibuprofen against pro-inflammatory inducible 5-lipoxygenase (IC50 ∼ 0.92 mg/mL). The lower hydrophobicity and steric variables were directly correlated with their antioxidative and anti-inflammatory properties. The studied compounds could be utilised as natural antioxidants and anti-inflammatory functional food ingredients.
 
Publisher Taylor and Francis
 
Date 2021
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/14948/1/Natural%20Product%20Research_2021_Kajal%20Chakraborty_Indian%20squid.pdf
Chakraborty, Kajal and Krishnan, Soumya and Joy, Minju (2021) Antioxidative oxygenated terpenoids with bioactivities against pro-inflammatory inducible enzymes from Indian squid, Uroteuthis (Photololigo) duvaucelii. Natural Product Research, 35 (6). pp. 1-12. ISSN 1478-6427 (Online)