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Oxaspiro Indiculides from Old Woman Octopus Cistopus indicus as Dual Inhibitors of Inducible Cyclooxygenase and Lipoxygenase

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Relation http://eprints.cmfri.org.in/16043/
https://doi.org/10.1002/cbdv.202200277
10.1002/cbdv.202200277
 
Title Oxaspiro Indiculides from Old Woman Octopus Cistopus indicus as Dual Inhibitors of Inducible Cyclooxygenase and Lipoxygenase
 
Creator Silpa, K P
Chakraborty, Kajal
 
Subject Biochemistry
Cephalopods
 
Description The organic extract of the old woman octopus Cistopus indicus (Octopodidae), ubiquitous in the Central and South Indo-Pacific to the tropical Indian Ocean, was chromatographically fractionated over a reverse-phase adsorbent to yield two oxygenated spiro heterocyclic compounds, named indiculides A and B. Their structures were elucidated by using comprehensive spectroscopic methods. The radical scavenging potential displayed by indiculide A (IC50 ∼1.2 mM) besides attenuating the cyclooxygenase isoforms (COX-1/COX-2; IC50 3.36/3.02 μM) showed considerably superior activities when equated to those showed by indiculide B (IC50 3.45/3.22 μM). The inhibition property of indiculide A against 5-LOX (IC50 2.57 μM) was significantly greater than that of the standard 5-LOX inhibitor zileuton (IC50 3.70 μM, p
 
Publisher Wiley
 
Date 2022
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/16043/1/Chemistry%20and%20Biodiversity_2022_Kajal%20Chakraborty.pdf
Silpa, K P and Chakraborty, Kajal (2022) Oxaspiro Indiculides from Old Woman Octopus Cistopus indicus as Dual Inhibitors of Inducible Cyclooxygenase and Lipoxygenase. Chemistry and Biodiversity. pp. 1-12.