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Disposition kinetics of sparfloxacin under different pathological condition in Black Bengal goat following single intravenous administration

Indian Agricultural Research Journals

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Title Disposition kinetics of sparfloxacin under different pathological condition in Black Bengal goat following single intravenous administration
 
Creator RAHAMAN, ABUL HASAN MD ABIDUR
KHAN, MADHUCHHAANDA
MANDAL, TAPAN KUMAR
 
Subject Carbontetrachloride, Disposition kinetics, Goats, Hepatopathy, Sparfloxacin
 
Description Clinically healthy 9 black Bengal female goats (1–1.5 year age) weighing between 9–12 kg were divided into 3 equal groups. Group 1 served as control and the animals of group 2 and 3 were considered to be experimental. In experiment no. 1 sparfloxacin was administered intravenously to the goats of group 1 and disposition kinetics and protein binding studies were conducted in plasma. Liver of each goat of group 2 and 3 were damaged by subcutaneous administration of carbontetrachloride and considered as experiment no.2. Sparfloxacin was administered intravenously to group 2 for disposition kinetics and protein binding study. In experiment no.3 rejuvenation of liver of animals of group 2 were done by oral administration of a commercial medicine for consecutive 21 days period. Animals of group 3 were considered as untreated control for the commercial medicine. The results of icterus index, bromosulphophthalein clearance, serum transaminase activity suggested that carbontetrachloride at the recommended dose level produced hepatopathy of goats. The commercial medicine treatment brought all the altered values of plasma kinetic parameters to base level and regenerated the damaged tissue of liver. Disposition kinetic study of sparfloxacin showed that carbontetrachloride –induced damage liver retained Sparfloxacin for same period with almost equi concentration.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2014-08-14
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/43212
 
Source The Indian Journal of Animal Sciences; Vol 84, No 8 (2014)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/43212/19160
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences