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Pnarmacokinetics and dosage regimen of amikacin in febrile cow calves

Indian Agricultural Research Journals

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Title Pnarmacokinetics and dosage regimen of amikacin in febrile cow calves
 
Creator SAINI, S P S
SRIVASTAVA, A K
 
Subject Amikacin, Aminoglycoside, Cow calves, Disposition kinetics Dosage regimen
 
Description Disposition kinetics and dosage regimen of amikacin were investigated in experimentally induced febrile male cow calves. Fever was induced with E. coli endotoxin (1ug.kg, i/v) and after induction of ever, amikacin was administered (10 mg/kg/i/v). At 1 min, the peak plasma level of amikacin was 133.6-+1.96 ug/ml and the minimum therapeutic concentrationwas maintained up to 12 hr. The distribution half-lives in perpheral compartments 1 and 2 were 0.06-+ hr and 0.068-+ 0.03 hr, respectively. The elimination half-life and volume of distribution were 4.10 -+0.13 hr and 0.35-+0.04 L/kg respectively. The values of total body clearance *(CIB) and T/P ratio were 0.05-+0.01 L/kg hr and 6.21-+0.78 respectively. To maintain the minimum therapeutic plasma concentration, the appropriate dosage regimen of amikacin in febrile cow calves would be 6 mg/kg followed by 5 mg/kg at 12 hr intervals.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2013-11-07
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/34590
 
Source The Indian Journal of Animal Sciences; Vol 67, No 6 (1997)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/34590/15322
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences