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An experimental study on the immunization of mice and rabbits with Pasteurella multocida toxoid

Indian Agricultural Research Journals

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Title An experimental study on the immunization of mice and rabbits with Pasteurella multocida toxoid
 
Creator Sunder, Jai
Kumar, A A
 
Subject Immunization; Pasteurella multocida toxoid; Rabbit
 
Description A toxigenic strain of Pasteurella multocida serotype A: 12 of goat origin was selected on the basis of its toxin yield amongst other 3 toxin producing strains with a view to study its immune response. A crude Pasteurella multocida toxin (PMT) was prepared by cell sonication method. The immune response of inactivated PMT (toxoid) was studied in mice and rabbit model. The immune status of vaccinated animals was determined by ELISA and challenge test with crude toxin and live culture. Mice vaccinated with 2 doses schedule comprising 10 mg and 100 mg by s/c route gave a protection level of 60.0% and 73.3%, respectively, on challenge with 200 mg of crude toxin. Almost same level of protection was observed when challenged with live culture, 0.2 ml s/c (10¯⁹). While rabbits immunized with 200 mg of toxoid by s/c routes were protected when challenged with 400 mg of crude toxin by intranasal route and also did not show any dermonecrotic effect of PMT when 300 mg of crude toxin was given by I/D route.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2012-07-06
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/21260
 
Source The Indian Journal of Animal Sciences; Vol 69, No 10 (1999)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/21260/10758
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences