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Row-column designs for investigational products vs. control comparisons in veterinary trials

Indian Agricultural Research Journals

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Field Value
 
Title Row-column designs for investigational products vs. control comparisons in veterinary trials
 
Creator VARGHESE, CINI
VARGHESE, ELDHO
KUMAR, ARVIND
 
Subject Active control, Canonical efficiency, Double diagonal Latin square, Nested model, Row column designs, Veterinary trials
 
Description Veterinary trials are generally conducted for drug testing which uses experimental designs like parallel group designs, incomplete block designs, row-column designs, crossover designs, etc. In trials that are specially planned for making comparisons between investigational products with control(s), row-column designs eliminating variation due to periods and animals are most suitable. The present study demonstrated 2 methods of constructing small and efficient rowcolumn designs for investigational products vs. control comparisons. The first method provides designs (Series-I) for number of investigational products < 20 along with variance of estimated elementary contrasts pertaining to various comparisons of interest. The limitation of these designs is that these designs cannot be obtained for comparing odd number of investigational products with one (two) control(s). The second method (Series-II) yields designs for comparing all odd prime number of investigational products with one(two) control(s) and fills almost all the gaps left by Series-I. Thus, both series together provide a wide range of small and efficient row-column designs suitable for comparing a group of investigational products with one (two) control(s). The canonical efficiency factor of both the series of designs in comparison to an orthogonal design having the same number of investigational products has also been calculated considering a nested model with observational units nested within experimental units. These designs are found to be highly efficient.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2013-08-13
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/32198
 
Source The Indian Journal of Animal Sciences; Vol 83, No 8 (2013)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/32198/14420
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences