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Recombinant canine stromelysin 3 inhibits drug induced apoptosis in vitro

Indian Agricultural Research Journals

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Title Recombinant canine stromelysin 3 inhibits drug induced apoptosis in vitro
 
Creator KUMAR, B V SUNIL
KATARIA, MEENA
MURTHY, REDDI V V S N
SAXENA, MEETA
SHARMA, BHASKAR
 
Subject Apoptosis, FACS, Matrix metalloproteinases, Stromelysin 3, Vinblastine
 
Description Matrix metalloproteinases (MMPs) are zinc metalloproteases having a pivotal role in extracellular matrix degradation, tumor growth, apoptosis, angiogenesis, invasion, and development of metastases. Stromelysin 3 (ST3) increased tumor take by suppressing cell apoptosis. Our present goal was to set up an in vitro model in which we could study this new function of ST3. For this purpose, we analysed effect of vinblastine, an anti-cancer drug, onST3 treated MDCK (Madin-Darby canine kidney) cells. We found a marked decrease in the percentage of vinblastine induced MDCK cell death when the cells were pre-treated with recombinant ST3 as assessed by FACS analysis. Our data confirmed and extended the anti-apoptotic function of ST3 in-vitro.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2015-01-23
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/46132
 
Source The Indian Journal of Animal Sciences; Vol 85, No 1 (2015)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/46132/19967
 
Rights Copyright (c) 2015 The Indian Journal of Animal Sciences