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Comparative evaluation of nitric oxide synthase inhibitors L-NAME and 7-NI for the management of arthritis in rabbits

Indian Agricultural Research Journals

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Title Comparative evaluation of nitric oxide synthase inhibitors L-NAME and 7-NI for the management of arthritis in rabbits
 
Creator Mohindrooi, J
Singh, G R
., Amarpau
Varshney, V P
Kinjavadekars, P
Bisht, G S
 
Subject Arthritis; Inflannnation; L-NAME; Pain; Rabbits; Stress; 7-NI
 
Description Efficacy ofNOS inhibitors L-NAME and 7-NI was compared in the management of pain, inflammation and stress caused by chemical aseptic arthritis in rabbits. The animals were observed for various behavioural, clinical and haematobiochemical changes at specific intervals. The results of the study supported the hypothesis that L-NAME and 7-NJ could attenuate the inflammatory response. Both drugs had almost similar synergistic action with dicJofenac sodium in the treatment of acute arthritis. Further, pre-traumatic use of L-NAME and 7-NI had clinically evident preemptive effect on inflammation, pain and traumatic stress in rabbits subjected to induced aseptic arthritis. 
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2011-03-01
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/4334
 
Source The Indian Journal of Animal Sciences; Vol 76, No 9 (2006)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/4334/1677
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences