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Benzimidazole resistance in gastrointestinal nematodes of small ruminants of Uttarakhand

Indian Agricultural Research Journals

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Title Benzimidazole resistance in gastrointestinal nematodes of small ruminants of Uttarakhand
 
Creator RIALCH, AJAYTA
VATSYA, STUTI
KUMAR, RAJEEV RANJAN
 
Subject Anthelmintic resistance, Benzimidazole, Gastrointestinal nematodes, Goat, Sheep
 
Description The status of benzimidazole (BZ) resistance in gastrointestinal nematodes (GIN) was studied in a total of four flocks of sheep namely UTs1, UTs2, UTs3 (Uttarkashi district) and Bs1 (Bageshwar district) and four goat flocks namely UTg1, UTg2, (Uttarkashi district) and Bg1 (Bageshwar district) and Ug1 (U.S. Nagar district) of Uttarakhand state using egg hatch assay (EHA) and larval development assay (LDA). EHA detected resistance in two out of eight flocks (UTs3 and Ug1). Arithmetic mean and range of ED50 value of susceptible group was found to be 0.043μg/ml and 0.020-0.063μg/ml, respectively, and the same for resistant group were found to be 0.121μg/ml and 0.102-0.141μg/ml, respectively. The arithmetic mean and range of ED99 value of susceptible group was recorded as 0.295μg/ml and 0.170-0.500μg/ml, respectively, and that of resistant group was observed to be 2.970μg/ml and 1.794-4.146μg/ml, respectively. The arithmetic mean and range of LC50 value of susceptible group was found 0.003μg/ml and 0.002-0.003μg/ml, respectively, and those of resistant group was found 0.0150μg/ml and 0.010-0.011μg/ml, respectively. While the arithmetic mean and range of LC99 value of susceptible group was found to be 0.010μg/ml and 0.007-0.011μg/ml, respectively and those of resistant group was observed to be 0.784μg/ml and 0.409-1.159μg/ml, respectively. Pooled coproculture examination revealed the presence of predominantly Haemonchus contortus, followed by Trichostrongylus spp., Oesophagostomum and Strongyloides, while infective larvae that survived in wells having higher concentrations of Thiabendazole were all Haemonchus with few Trichostrongylus. BZ resistance has not been reported earlier against Trichostrongylus spp. from Uttarakhand. For effective management of GIN in small ruminants, evaluation of efficacy of anthelmintics is important to regularly monitor anthelmintic resistance. The baseline information thus generated will enable timely management of benzimidazoles resistance in GIN.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor
 
Date 2015-07-16
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion

 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/50237
 
Source The Indian Journal of Animal Sciences; Vol 85, No 7 (2015)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/50237/21463
 
Rights Copyright (c) 2015 The Indian Journal of Animal Sciences