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Effect of Piper longum Linn. in monosodium glutamate toxicity in rats

Indian Agricultural Research Journals

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Title Effect of Piper longum Linn. in monosodium glutamate toxicity in rats
 
Creator THOMAS, MARIYAMMA
GEORGE, SISILAMMA
 
Subject GSH; Lipid peroxides; Monosodium glutamate; Oxidative stress; Piper longum
 
Description Effect of ethanol extract of Piper longum (P. longum) Linn. in monosodium glutamate (MSG) induced toxicity was studied in rats. Oral administration of MSG at a dose of 8 mg/g body weight for 20 consecutive days showed an increase in body weight and liver weight. Oxidative stress was evidenced by significant increase in the level of lipid peroxides and decrease in reduced glutathione (GSH) content of serum, liver and kidney. There was significant increase in serum ALT and AST activities. Level of serum urea increased significantly whereas creatinine level did not altered. Significant increase was also observed in the levels of serum triacylglycerol and total cholesterol. Histopathological examination revealed degeneration and necrosis of hepatocytes, renal tubules and glomeruli of liver and kidney respectively. Rats treated with ethanol extract of P. longum fruits at 300 mg/kg body weight and 600 mg/kg body weight for 14 days significantly decreased body weight, serum triacylglycerol, lipid peroxides in serum, liver and kidney, serum ALT and AST activities and increased the content of GSH in serum, liver and kidney. However, 300 mg/kg body weight was found to be more effective in decreasing the level of triacylglycerol, serum ALT, lipid peroxides in serum, liver and kidney and increasing the content of GSH in serum and liver. Significant reduction in liver weight and serum cholesterol was observed only in rats treated with the extract at this dose. Serum urea level did not vary significantly between treated groups and positive control. Histopathological examination of liver and kidney showed normal histological architecture except for mild congestion. The present study revealed that ethanol extract of fruits of P. longum has antioxidant and hypolipidaemic properties and may be used for treating MSG toxicity.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor ICAR
 
Date 2010-09-09
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/852
 
Source The Indian Journal of Animal Sciences; Vol 80, No 9 (2010)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/852/353
 
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