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Diminazene: Bioavailability and disposition in bovine calves

Indian Agricultural Research Journals

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Title Diminazene: Bioavailability and disposition in bovine calves
 
Creator SARDAR, K K
PARIJA, S C
MISRA, S N
 
Subject —
 
Description The pharmacokinctic behaviour of diminazene diaceturate in plasma was &ludied in 6 clinically healthy crossbred female Jersey calves. Following i/m injection @ 16 mg/kg, the volume of distribution was 1.254 ± 0.076 L/kg, total body clearance averaged 0.564 ± 0.090 ml/kg/min and elimination half-life was 31.604 ± 2.296 hr. At 0.5 hr following the injection, the plasma diminazene concentration was 20.91 ± 1.16 mug/ml which gradually declined to 6.75 ± 0.80 pg/ml at 24 hr. The study indicated that an initial i/m dose of 16 mg/kg followed by 8 mg/kg at 48-72 hr may be safe and effective in cases of babesios.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2013-08-05
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/31933
 
Source The Indian Journal of Animal Sciences; Vol 65, No 8 (1995)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/31933/14311
 
Rights Copyright (c) 2014 The Indian Journal of Animal Sciences