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Anthelmintic activity of Sesbania grandiflora against gastrointestinal nematodes of sheep

Indian Agricultural Research Journals

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Title Anthelmintic activity of Sesbania grandiflora against gastrointestinal nematodes of sheep
 
Creator MEENAKSHISUNDARAM, A
HARIKRISHNAN, T J
ANNA, T
 
Subject Anthelmintic, Evaluation, GI nematodes, Sesbania grandiflora, Sheep
 
Description The study was carried out to validate the anthelmintic efficacy of Sesbania grandiflora and to standardize the effective dose of the plant extract required for worm control in livestock. In vitro and in vivo studies were conducted to determine the direct anthelmintic effect of ethanolic and aqueous extracts of S. grandiflora towards mixed ovine gastrointestinal nematodes. Egg hatch assay for ovicidal and larval migration inhibition and larval development assay for larvicidal properties were used to investigate in vitro effect of extracts on strongyle egg and larvae. Faecal egg count reduction test was conducted in vivo to evaluate the therapeutic efficacy of the extacts administered orally @ 125, 250, 500 mg/kg to sheep naturally infected with mixed gastrointestinal nematodes. Aqueous extract of S. grandiflora demonstrated significant inhibition of egg hatch and larval migration @ 40 and 80 mg/ml. The ED50 value of egg hatch inhibition and LM50 value for larval migration inhibition were 1.489 and 0.683 mg/ml respectively. In faecal egg count reduction test (FECRT), aqueous extract of S. grandiflora at 500 mg/kg caused significant reduction in eggs per gram (98.10 %) higher than the result obtained with albendazole (93.25 %). Although there were slight variations in the haematological parameters (PCV, haemoglobin, RBC and WBC) in all the groups between day 0 and 12, all the parameters were within the normal range reported for sheep. Except for blood urea nitrogen, overall mean of all the serum biochemical profile was within the normal range for sheep. Based on the results obtained by in vitro and in vivo assay, the aqueous extract of S. grandiflora possess anthelmintic activity and could offer an alternative source for the control of gastrointestinal nematodes of sheep.
 
Publisher Directorate of Knowledge Management in Agriculture
 
Contributor —
 
Date 2016-02-11
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
—
 
Format application/pdf
 
Identifier http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/55776
 
Source The Indian Journal of Animal Sciences; Vol 86, No 2 (2016)
0367-8318
 
Language eng
 
Relation http://epubs.icar.org.in/ejournal/index.php/IJAnS/article/view/55776/23453
 
Rights Copyright (c) 2016 The Indian Journal of Animal Sciences