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Apoptotic effect of chromanone derivative, hyrtiosone A from marine demosponge Hyrtios erectus in hepatocellular carcinoma HepG2 cells

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Relation http://eprints.cmfri.org.in/15162/
https://www.sciencedirect.com/science/article/pii/S004520682100496X
https://doi.org/10.1016/j.bioorg.2021.105119
 
Title Apoptotic effect of chromanone derivative, hyrtiosone A from marine demosponge Hyrtios erectus in hepatocellular carcinoma HepG2 cells
 
Creator Chakraborty, Kajal
Francis, Prima
 
Subject Bioprospecting
Biochemistry
Sponges
 
Description The tumor suppressor proteins p53 and p27 exhibited a significant role in the survival of cells and regulation of cellular division and growth. In majority of the human tumors, particularly in hepatocellular carcinoma, these proteins are inactivated by mutation or deletion, and are considered to predict the pathophysiology related to liver cancer. The present study evaluated the activation of the p53 and p27 pathways as a useful therapeutic tool to attenuate hepatocellular carcinoma. Three undescribed homologous chromanone derivatives, hyrtiosones A-C were isolated from the organic extract of marine demosponge Hyrtios erectus (family Thorectidae). Preliminary bioactivity assessments found that hyrtiosone A exhibited prospective anti-inflammatory (IC50 1.02-1.86 mM) and antioxidant (IC50 0.74-0.83 mM) properties. Molecular docking analysis of the hyrtiosones using p53-murine double minute complex revealed lesser docking parameters for hyrtiosone A (binding energy
 
Date 2021
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/15162/1/Bioorganic%20Chemistry_2021_Kajal%20Chakraborty_Apoptotic%20effect%20of%20hyrtiosone%20A%20from%20Hyrtios%20erectus.pdf
Chakraborty, Kajal and Francis, Prima (2021) Apoptotic effect of chromanone derivative, hyrtiosone A from marine demosponge Hyrtios erectus in hepatocellular carcinoma HepG2 cells. Bioorganic Chemistry, 114. pp. 1-14.